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Research Article

Two Separate Interfaces between the Voltage Sensor and Pore Are Required for the Function of Voltage-Dependent K+ Channels

  • Seok-Yong Lee equal contributor,

    equal contributor Contributed equally to this work with: Seok-Yong Lee, Anirban Banerjee

    Affiliations: Howard Hughes Medical Institute, Rockefeller University, New York, New York, United States of America, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, New York, New York, United States of America

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  • Anirban Banerjee equal contributor,

    equal contributor Contributed equally to this work with: Seok-Yong Lee, Anirban Banerjee

    Affiliations: Howard Hughes Medical Institute, Rockefeller University, New York, New York, United States of America, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, New York, New York, United States of America

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  • Roderick MacKinnon mail

    To whom correspondence should be addressed. E-mail: mackinn@mail.rockefeller.edu

    Affiliations: Howard Hughes Medical Institute, Rockefeller University, New York, New York, United States of America, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, New York, New York, United States of America

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  • Published: March 03, 2009
  • DOI: 10.1371/journal.pbio.1000047

About the Authors

Seok-Yong Lee, Anirban Banerjee, Roderick MacKinnon
Howard Hughes Medical Institute, Rockefeller University, New York, New York, United States of America
Seok-Yong Lee, Anirban Banerjee, Roderick MacKinnon
Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, New York, New York, United States of America

Corresponding Author

Email: mackinn@mail.rockefeller.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

S-YL, AB, and RM conceived and designed the experiments. S-YL and AB performed the experiments. S-YL, AB, and RM analyzed the data and wrote the paper.