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Research Article

The Structural Basis of Gas-Responsive Transcription by the Human Nuclear Hormone Receptor REV-ERBβ

  • Keith I Pardee,

    Affiliations: Banting and Best Department of Medical Research, The Department of Molecular Genetics, University of Toronto, Toronto, Canada, Terrence Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, Canada

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  • Xiaohui Xu,

    Affiliations: Banting and Best Department of Medical Research, The Department of Molecular Genetics, University of Toronto, Toronto, Canada, Terrence Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, Canada, Midwest Center for Structural Genomics, University of Toronto, Toronto, Canada

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  • Jeff Reinking,

    Affiliations: Banting and Best Department of Medical Research, The Department of Molecular Genetics, University of Toronto, Toronto, Canada, Terrence Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, Canada, Department of Biology, State University of New York at New Paltz, New Paltz, New York, United States of America

    ¤a Current address: Department of Structural and Chemical Biology, Ichah Medical Institute, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Anja Schuetz,

    Affiliation: Structural Genomics Consortium, University of Toronto, Toronto, Canada

    ¤b Current address: Protein Sample Production Facility, Max Delbrück Center for Molecular Medicine, Berlin, Germany

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  • Aiping Dong,

    Affiliation: Structural Genomics Consortium, University of Toronto, Toronto, Canada

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  • Suya Liu,

    Affiliation: Department of Biochemistry, University of Western Ontario, London, Ontario, Canada

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  • Rongguang Zhang,

    Affiliation: Midwest Center for Structural Genomics, Argonne National Lab, Argonne, Illinois, United States of America

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  • Jens Tiefenbach,

    Affiliations: Banting and Best Department of Medical Research, The Department of Molecular Genetics, University of Toronto, Toronto, Canada, Terrence Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, Canada

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  • Gilles Lajoie,

    Affiliation: Department of Biochemistry, University of Western Ontario, London, Ontario, Canada

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  • Alexander N Plotnikov,

    Affiliation: Structural Genomics Consortium, University of Toronto, Toronto, Canada

    ¤b Current address: Protein Sample Production Facility, Max Delbrück Center for Molecular Medicine, Berlin, Germany

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  • Alexey Botchkarev,

    Affiliation: Structural Genomics Consortium, University of Toronto, Toronto, Canada

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  • Henry M Krause mail,

    To whom correspondence should be addressed. E-mail: aled.edwards@utoronto.ca (AE); h.krause@utoronto.ca (HMK)

    Affiliations: Banting and Best Department of Medical Research, The Department of Molecular Genetics, University of Toronto, Toronto, Canada, Terrence Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, Canada

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  • Aled Edwards mail

    To whom correspondence should be addressed. E-mail: aled.edwards@utoronto.ca (AE); h.krause@utoronto.ca (HMK)

    Affiliations: Banting and Best Department of Medical Research, The Department of Molecular Genetics, University of Toronto, Toronto, Canada, Terrence Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, Canada, Midwest Center for Structural Genomics, University of Toronto, Toronto, Canada, Structural Genomics Consortium, University of Toronto, Toronto, Canada

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  • Published: February 24, 2009
  • DOI: 10.1371/journal.pbio.1000043

About the Authors

Keith I Pardee, Xiaohui Xu, Jeff Reinking, Jens Tiefenbach, Henry M Krause, Aled Edwards
Banting and Best Department of Medical Research, The Department of Molecular Genetics, University of Toronto, Toronto, Canada
Keith I Pardee, Xiaohui Xu, Jeff Reinking, Jens Tiefenbach, Henry M Krause, Aled Edwards
Terrence Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, Canada
Xiaohui Xu, Aled Edwards
Midwest Center for Structural Genomics, University of Toronto, Toronto, Canada
Anja Schuetz, Aiping Dong, Alexander N Plotnikov, Alexey Botchkarev, Aled Edwards
Structural Genomics Consortium, University of Toronto, Toronto, Canada
Suya Liu, Gilles Lajoie
Department of Biochemistry, University of Western Ontario, London, Ontario, Canada
Rongguang Zhang
Midwest Center for Structural Genomics, Argonne National Lab, Argonne, Illinois, United States of America
Jeff Reinking
Department of Biology, State University of New York at New Paltz, New Paltz, New York, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

KIP, JR, AS, JT, ANP, HMK, and AE conceived and designed the experiments. KIP, XX, JR, AS, AD, SL, and RZ performed the experiments. KIP, JR, AS, AD, SL, JT, ANP, AB, HMK, and AE analyzed the data. GL contributed reagents/materials/analysis tools. KIP, HMK and AE wrote the paper.