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Research Article

Neto1 Is a Novel CUB-Domain NMDA Receptor–Interacting Protein Required for Synaptic Plasticity and Learning

  • David Ng equal contributor,

    equal contributor Contributed equally to this work with: David Ng, Graham M Pitcher

    Affiliations: Program in Developmental Biology, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada, Program in Genetics & Genome Biology, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada, Neurosciences & Mental Health, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada

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  • Graham M Pitcher equal contributor,

    equal contributor Contributed equally to this work with: David Ng, Graham M Pitcher

    Affiliations: Neurosciences & Mental Health, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada, Department of Physiology, University of Toronto, Toronto, Ontario, Canada

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  • Rachel K Szilard,

    Affiliations: Program in Developmental Biology, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada, Program in Genetics & Genome Biology, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada

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  • Andréa Sertié,

    Affiliations: Program in Developmental Biology, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada, Program in Genetics & Genome Biology, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada

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  • Marijana Kanisek,

    Affiliations: Department of Physiology, University of Toronto, Toronto, Ontario, Canada, Mount Sinai Hospital Research Institute, Toronto, Ontario, Canada

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  • Steven J Clapcote,

    Affiliation: Mount Sinai Hospital Research Institute, Toronto, Ontario, Canada

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  • Tatiana Lipina,

    Affiliation: Mount Sinai Hospital Research Institute, Toronto, Ontario, Canada

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  • Lorraine V Kalia,

    Affiliations: Neurosciences & Mental Health, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada, Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada

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  • Daisy Joo,

    Affiliation: Neurosciences & Mental Health, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada

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  • Colin McKerlie,

    Affiliation: Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada

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  • Miguel Cortez,

    Affiliation: Neurosciences & Mental Health, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada

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  • John C Roder,

    Affiliations: Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada, Mount Sinai Hospital Research Institute, Toronto, Ontario, Canada

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  • Michael W Salter mail,

    To whom correspondence should be addressed. E-mail: mike.salter@utoronto.ca (MWS); mcinnes@sickkids.ca (RRM)

    Affiliations: Neurosciences & Mental Health, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada, Department of Physiology, University of Toronto, Toronto, Ontario, Canada, Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada

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  • Roderick R McInnes mail

    To whom correspondence should be addressed. E-mail: mike.salter@utoronto.ca (MWS); mcinnes@sickkids.ca (RRM)

    Affiliations: Program in Developmental Biology, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada, Program in Genetics & Genome Biology, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada, Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada

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  • Published: February 24, 2009
  • DOI: 10.1371/journal.pbio.1000041

About the Authors

David Ng, Rachel K Szilard, Andréa Sertié, Roderick R McInnes
Program in Developmental Biology, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
David Ng, Rachel K Szilard, Andréa Sertié, Roderick R McInnes
Program in Genetics & Genome Biology, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
David Ng, John C Roder, Roderick R McInnes
Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
David Ng, Graham M Pitcher, Lorraine V Kalia, Daisy Joo, Miguel Cortez, Michael W Salter
Neurosciences & Mental Health, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
Graham M Pitcher, Marijana Kanisek, Michael W Salter
Department of Physiology, University of Toronto, Toronto, Ontario, Canada
Marijana Kanisek, Steven J Clapcote, Tatiana Lipina, John C Roder
Mount Sinai Hospital Research Institute, Toronto, Ontario, Canada
Lorraine V Kalia, Michael W Salter, Roderick R McInnes
Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
Colin McKerlie
Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada
Roderick R McInnes
Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

DN, GMP, RKS, AS, MK, SJC, TL, JCR, MWS, and RRM conceived and designed the experiments. DN, GMP, RKS, AS, MK, SJC, TL, DJ, and MC performed the experiments. DN, GMP, RKS, AS, MK, SJC, TL, DJ, CM, MC, MWS, and RRM analyzed the data. LVK contributed reagents/materials/analysis tools. DN, GMP, MWS, and RRM wrote the paper.