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Research Article

Neuropilin-1/GIPC1 Signaling Regulates α5β1 Integrin Traffic and Function in Endothelial Cells

  • Donatella Valdembri,

    Affiliation: Department of Oncological Sciences and Division of Molecular Angiogenesis, Institute for Cancer Research and Treatment, University of Torino School of Medicine, Candiolo, Italy

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  • Patrick T Caswell,

    Affiliation: Beatson Institute for Cancer Research, Bearsden, Glasgow, United Kingdom

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  • Kurt I Anderson,

    Affiliation: Beatson Institute for Cancer Research, Bearsden, Glasgow, United Kingdom

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  • Juliane P Schwarz,

    Affiliation: Beatson Institute for Cancer Research, Bearsden, Glasgow, United Kingdom

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  • Ireen König,

    Affiliation: Beatson Institute for Cancer Research, Bearsden, Glasgow, United Kingdom

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  • Elena Astanina,

    Affiliation: Department of Oncological Sciences and Division of Molecular Angiogenesis, Institute for Cancer Research and Treatment, University of Torino School of Medicine, Candiolo, Italy

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  • Francesca Caccavari,

    Affiliation: Department of Oncological Sciences and Division of Molecular Angiogenesis, Institute for Cancer Research and Treatment, University of Torino School of Medicine, Candiolo, Italy

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  • Jim C Norman,

    Affiliation: Beatson Institute for Cancer Research, Bearsden, Glasgow, United Kingdom

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  • Martin J Humphries,

    Affiliation: Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom

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  • Federico Bussolino,

    Affiliations: Department of Oncological Sciences and Division of Molecular Angiogenesis, Institute for Cancer Research and Treatment, University of Torino School of Medicine, Candiolo, Italy, Center for Complex Systems in Molecular Biology and Medicine, University of Torino, Torino, Italy

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  • Guido Serini mail

    To whom correspondence should be addressed. E-mail: guido.serini@ircc.it

    Affiliations: Department of Oncological Sciences and Division of Molecular Angiogenesis, Institute for Cancer Research and Treatment, University of Torino School of Medicine, Candiolo, Italy, Center for Complex Systems in Molecular Biology and Medicine, University of Torino, Torino, Italy

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  • Published: January 27, 2009
  • DOI: 10.1371/journal.pbio.1000025

About the Authors

Donatella Valdembri, Elena Astanina, Francesca Caccavari, Federico Bussolino, Guido Serini
Department of Oncological Sciences and Division of Molecular Angiogenesis, Institute for Cancer Research and Treatment, University of Torino School of Medicine, Candiolo, Italy
Patrick T Caswell, Kurt I Anderson, Juliane P Schwarz, Ireen König, Jim C Norman
Beatson Institute for Cancer Research, Bearsden, Glasgow, United Kingdom
Martin J Humphries
Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
Federico Bussolino, Guido Serini
Center for Complex Systems in Molecular Biology and Medicine, University of Torino, Torino, Italy

Corresponding Author

Email: guido.serini@ircc.it

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

DV, PTC, KIA, JCN, and GS conceived and designed the experiments. DV, PTC, JPS, IK, EA, and FC performed the experiments. DV, PTC, KIA, JPS, IK, EA, JCN, FB, and GS analyzed the data. KIA, JCN, and MJH contributed reagents/materials/analysis tools. DV, JPS, IK, JCN, FB, and GS wrote the paper.