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Research Article

High Functional Diversity in Mycobacterium tuberculosis Driven by Genetic Drift and Human Demography

  • Ruth Hershberg equal contributor,

    equal contributor Contributed equally to this work with: Ruth Hershberg, Mikhail Lipatov

    Affiliation: Department of Biology, Stanford University, Stanford, California, United States of America

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  • Mikhail Lipatov equal contributor,

    equal contributor Contributed equally to this work with: Ruth Hershberg, Mikhail Lipatov

    Affiliation: Department of Biology, Stanford University, Stanford, California, United States of America

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  • Peter M Small,

    Affiliations: Institute for Systems Biology, Seattle, Washington, United States of America, Bill and Melinda Gates Foundation, Seattle, Washington, United States of America

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  • Hadar Sheffer,

    Affiliation: Institute for Systems Biology, Seattle, Washington, United States of America

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  • Stefan Niemann,

    Affiliation: Forschungszentrum Borstel, National Reference Center for Mycobacteria, Borstel, Germany

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  • Susanne Homolka,

    Affiliation: Forschungszentrum Borstel, National Reference Center for Mycobacteria, Borstel, Germany

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  • Jared C Roach,

    Affiliation: Seattle Children's Hospital Research Institute, Seattle, Washington, United States of America

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  • Kristin Kremer,

    Affiliation: Mycobacteria Reference Unit (CIb-LIS), National Institute of Public Health and the Environment, Bilthoven, The Netherlands

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  • Dmitri A Petrov,

    Affiliation: Department of Biology, Stanford University, Stanford, California, United States of America

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  • Marcus W Feldman,

    Affiliation: Department of Biology, Stanford University, Stanford, California, United States of America

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  • Sebastien Gagneux mail

    To whom correspondence should be addressed. E-mail: gagneux@nimr.mrc.ac.uk

    Affiliations: Institute for Systems Biology, Seattle, Washington, United States of America, MRC National Institute for Medical Research, London, United Kingdom

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  • Published: December 16, 2008
  • DOI: 10.1371/journal.pbio.0060311

About the Authors

Ruth Hershberg, Mikhail Lipatov, Dmitri A Petrov, Marcus W Feldman
Department of Biology, Stanford University, Stanford, California, United States of America
Peter M Small, Hadar Sheffer, Sebastien Gagneux
Institute for Systems Biology, Seattle, Washington, United States of America
Peter M Small
Bill and Melinda Gates Foundation, Seattle, Washington, United States of America
Stefan Niemann, Susanne Homolka
Forschungszentrum Borstel, National Reference Center for Mycobacteria, Borstel, Germany
Jared C Roach
Seattle Children's Hospital Research Institute, Seattle, Washington, United States of America
Kristin Kremer
Mycobacteria Reference Unit (CIb-LIS), National Institute of Public Health and the Environment, Bilthoven, The Netherlands
Sebastien Gagneux
MRC National Institute for Medical Research, London, United Kingdom

Corresponding Author

Email: gagneux@nimr.mrc.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

RH, ML, PMS, DAP, MWF, and SG conceived and designed the experiments. RH, ML, HS, SH, and SG performed the experiments. RH, ML, SN, SH, JCR, and SG analyzed the data. PMS, SN, KK, and SG contributed reagents/materials/analysis tools. RH, ML, PMS, DAP, MWF, and SG wrote the paper.