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Research Article

Chromatin- and Transcription-Related Factors Repress Transcription from within Coding Regions throughout the Saccharomyces cerevisiae Genome

  • Vanessa Cheung,

    Affiliation: Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Gordon Chua,

    Affiliation: Banting and Best Department of Medical Research, University of Toronto, Toronto, Canada

    ¤a Current address: Department of Biological Sciences, University of Calgary, Calgary, Canada

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  • Nizar N Batada,

    Affiliation: Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

    ¤b Current address: Ontario Institute for Cancer Research, Toronto, Canada

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  • Christian R Landry,

    Affiliation: Département de Biochimie, and Centre Robert-Cedergren, Bio-Informatique Génomique, Université de Montréal, Montréal, Canada

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  • Stephen W Michnick,

    Affiliation: Département de Biochimie, and Centre Robert-Cedergren, Bio-Informatique Génomique, Université de Montréal, Montréal, Canada

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  • Timothy R Hughes,

    Affiliation: Banting and Best Department of Medical Research, University of Toronto, Toronto, Canada

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  • Fred Winston mail

    To whom correspondence should be addressed. E-mail: winston@genetics.med.harvard.edu

    Affiliation: Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: November 11, 2008
  • DOI: 10.1371/journal.pbio.0060277

About the Authors

Vanessa Cheung, Nizar N Batada, Fred Winston
Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
Gordon Chua, Timothy R Hughes
Banting and Best Department of Medical Research, University of Toronto, Toronto, Canada
Christian R Landry, Stephen W Michnick
Département de Biochimie, and Centre Robert-Cedergren, Bio-Informatique Génomique, Université de Montréal, Montréal, Canada

Corresponding Author

Email: winston@genetics.med.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

VC, GC, NNB, CRL, SWM, TRH, and FW conceived and designed the experiments. VC, GC, NNB, and CRL performed the experiments. VC and FW wrote the paper with contributions from GC, NNB, CRL, SWM, and TRH.