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Research Article

Evolution Acts on Enhancer Organization to Fine-Tune Gradient Threshold Readouts

  • Justin Crocker,

    Affiliation: Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire, United States of America

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  • Yoichiro Tamori,

    Affiliation: Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire, United States of America

    ยค Current address: Department of Biological Sciences, Florida State University, Tallahassee, Florida, United States of America

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  • Albert Erives mail

    To whom correspondence should be addressed. E-mail: albert.erives@dartmouth.edu

    Affiliation: Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire, United States of America

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  • Published: November 04, 2008
  • DOI: 10.1371/journal.pbio.0060263

About the Authors

Justin Crocker, Yoichiro Tamori, Albert Erives
Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire, United States of America

Corresponding Author

Email: albert.erives@dartmouth.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

AE conceived and directed the work. JC conducted the whole-genome bioinformatic analyses, constructed all of the transgenic animals, and performed in situ hybridization assays. AE and JC analyzed all the data. YT assisted with characterization of the sog locus. AE wrote the paper. All authors commented on the manuscript.