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Research Article

Interconvertible Lac Repressor–DNA Loops Revealed by Single-Molecule Experiments

  • Oi Kwan Wong,

    Affiliation: Department of Biochemistry, Brandeis University, Waltham, Massachusetts, United States of America

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  • Martin Guthold,

    Affiliation: Department of Physics, Wake Forest University, Winston-Salem, North Carolina, United States of America

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  • Dorothy A Erie,

    Affiliation: Department of Chemistry and Curriculum Applied and Materials Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Jeff Gelles mail

    To whom correspondence should be addressed. E-mail: gelles@brandeis.edu

    Affiliation: Department of Biochemistry, Brandeis University, Waltham, Massachusetts, United States of America

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  • Published: September 30, 2008
  • DOI: 10.1371/journal.pbio.0060232

About the Authors

Oi Kwan Wong, Jeff Gelles
Department of Biochemistry, Brandeis University, Waltham, Massachusetts, United States of America
Martin Guthold
Department of Physics, Wake Forest University, Winston-Salem, North Carolina, United States of America
Dorothy A Erie
Department of Chemistry and Curriculum Applied and Materials Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Corresponding Author

Email: gelles@brandeis.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

OKW, MG, DAE, and JG conceived and designed the experiments. OKW and MG performed the experiments. OKW, MG, DAE, and JG analyzed the data. OKW, DAE, and JG wrote the paper. All authors reviewed and edited the manuscript.