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Research Article

Dual Role of Topoisomerase II in Centromere Resolution and Aurora B Activity

  • Paula A Coelho,

    Affiliation: Instituto de Biologia Molecular e Celular (IBMC), Porto, Portugal

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  • Joana Queiroz-Machado,

    Affiliations: Instituto de Biologia Molecular e Celular (IBMC), Porto, Portugal, Faculdade de Ciências da Saúde, Universidade Fernando Pessoa, Porto, Portugal

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  • Alexandre M Carmo,

    Affiliation: Instituto de Biologia Molecular e Celular (IBMC), Porto, Portugal

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  • Sara Moutinho-Pereira,

    Affiliation: Instituto de Biologia Molecular e Celular (IBMC), Porto, Portugal

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  • Helder Maiato,

    Affiliations: Instituto de Biologia Molecular e Celular (IBMC), Porto, Portugal, Laboratory of Cell and Molecular Biology, Faculdade de Medicina, Universidade do Porto, Porto, Portugal

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  • Claudio E Sunkel mail

    To whom correspondence should be addressed. E-mail: cesunkel@ibmc.up.pt

    Affiliations: Instituto de Biologia Molecular e Celular (IBMC), Porto, Portugal, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal

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  • Published: August 26, 2008
  • DOI: 10.1371/journal.pbio.0060207

About the Authors

Paula A Coelho, Joana Queiroz-Machado, Alexandre M Carmo, Sara Moutinho-Pereira, Helder Maiato, Claudio E Sunkel
Instituto de Biologia Molecular e Celular (IBMC), Porto, Portugal
Joana Queiroz-Machado
Faculdade de Ciências da Saúde, Universidade Fernando Pessoa, Porto, Portugal
Helder Maiato
Laboratory of Cell and Molecular Biology, Faculdade de Medicina, Universidade do Porto, Porto, Portugal
Claudio E Sunkel
Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal

Corresponding Author

Email: cesunkel@ibmc.up.pt

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

PAC and CES conceived and designed the experiments. PAC performed the experiments. PAC and CES analyzed the data. PAC, JQM, AMC, SMP, HM, and CES contributed reagents/materials/analysis tools. PAC and CES wrote the paper.