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Research Article

A Novel Molecular Solution for Ultraviolet Light Detection in Caenorhabditis elegans

  • Stacey L Edwards,

    Affiliation: Genetic Models of Disease Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

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  • Nicole K Charlie,

    Affiliation: Genetic Models of Disease Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

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  • Marie C Milfort,

    Affiliation: Genetic Models of Disease Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

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  • Brandon S Brown,

    Affiliation: Genetic Models of Disease Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

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  • Christen N Gravlin,

    Affiliation: Genetic Models of Disease Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

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  • Jamie E Knecht,

    Affiliation: Genetic Models of Disease Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

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  • Kenneth G Miller mail

    To whom correspondence should be addressed. E-mail: millerk@omrf.org

    Affiliation: Genetic Models of Disease Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

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  • Published: August 05, 2008
  • DOI: 10.1371/journal.pbio.0060198

About the Authors

Stacey L Edwards, Nicole K Charlie, Marie C Milfort, Brandon S Brown, Christen N Gravlin, Jamie E Knecht, Kenneth G Miller
Genetic Models of Disease Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

Corresponding Author

Email: millerk@omrf.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

SLE ran the genetic screen and mapped the mutations. SLE, MCM, and BSB isolated most of the lite-1 mutants, although all authors found Lite mutants. SLE and NKC did most of the live animal assays and produced the DNA constructs and transgenic strains, with contributions from MCM and BSB. KGM discovered the light response, designed the experiments, obtained video and fluorescence images, and wrote the paper.