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Research Article

Novel Intermolecular Iterative Mechanism for Biosynthesis of Mycoketide Catalyzed by a Bimodular Polyketide Synthase

  • Tarun Chopra,

    Affiliation: National Institute of Immunology, New Delhi, India

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  • Srijita Banerjee,

    Affiliation: National Institute of Immunology, New Delhi, India

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  • Sarika Gupta,

    Affiliation: National Institute of Immunology, New Delhi, India

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  • Gitanjali Yadav,

    Affiliation: National Institute of Immunology, New Delhi, India

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  • Swadha Anand,

    Affiliation: National Institute of Immunology, New Delhi, India

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  • Avadhesha Surolia,

    Affiliation: National Institute of Immunology, New Delhi, India

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  • Rajendra P Roy,

    Affiliation: National Institute of Immunology, New Delhi, India

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  • Debasisa Mohanty,

    Affiliation: National Institute of Immunology, New Delhi, India

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  • Rajesh S Gokhale mail

    To whom correspondence should be addressed. E-mail: rsg@nii.res.in

    Affiliation: National Institute of Immunology, New Delhi, India

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  • Published: July 08, 2008
  • DOI: 10.1371/journal.pbio.0060163

About the Authors

Tarun Chopra, Srijita Banerjee, Sarika Gupta, Gitanjali Yadav, Swadha Anand, Avadhesha Surolia, Rajendra P Roy, Debasisa Mohanty, Rajesh S Gokhale
National Institute of Immunology, New Delhi, India

Corresponding Author

Email: rsg@nii.res.in

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

TC carried out cloning, expression, purification, and biochemical characterization of pks12 and all other related constructs. SB carried out analytical ultracentrifugation studies in RPR's laboratory. TC and GY carried out the bioinformatic analysis of pks12. SA built the PKS12 model in DM's laboratory. SG and AS contributed to AFM studies. RSG directed the project. TC, DM, and RSG compiled results and wrote the manuscript.