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Research Article

Dynamics and Design Principles of a Basic Regulatory Architecture Controlling Metabolic Pathways

  • Chen-Shan Chin equal contributor,

    equal contributor Contributed equally to this work with: Chen-Shan Chin, Victor Chubukov

    Affiliation: Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America

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  • Victor Chubukov equal contributor,

    equal contributor Contributed equally to this work with: Chen-Shan Chin, Victor Chubukov

    Affiliations: Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America, Joint Graduate Group in Bioengineering, University of California, Berkeley, and University of California, San Francisco, San Francisco, California, United States of America

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  • Emmitt R Jolly,

    Affiliation: Department of Pathology, University of California, San Francisco, San Francisco, California, United States of America

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  • Joe DeRisi,

    Affiliation: Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America

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  • Hao Li mail

    To whom correspondence should be addressed. E-mail: haoli@genome.ucsf.edu

    Affiliations: Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America, Joint Graduate Group in Bioengineering, University of California, Berkeley, and University of California, San Francisco, San Francisco, California, United States of America, Center for Theoretical Biology, Peking University, Beijing, China

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  • Published: June 17, 2008
  • DOI: 10.1371/journal.pbio.0060146

About the Authors

Chen-Shan Chin, Victor Chubukov, Joe DeRisi, Hao Li
Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America
Emmitt R Jolly
Department of Pathology, University of California, San Francisco, San Francisco, California, United States of America
Victor Chubukov, Hao Li
Joint Graduate Group in Bioengineering, University of California, Berkeley, and University of California, San Francisco, San Francisco, California, United States of America
Hao Li
Center for Theoretical Biology, Peking University, Beijing, China

Corresponding Author

Email: haoli@genome.ucsf.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

CC, VC, JD, and HL conceived and design the experiments. CC set up the automated system. CC and VC did the experiments. EJ constructed a number of mutant strains. CC, VC, and HL analyzed data and developed the mathematical model. CC, VC, JD, and HL wrote the manuscript.