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Research Article

Mapping the Genetic Architecture of Gene Expression in Human Liver

  • Eric E Schadt equal contributor,

    equal contributor Contributed equally to this work with: Eric E Schadt, Cliona Molony, Eugene Chudin

    Affiliation: Rosetta Inpharmatics, Seattle, Washington, United States of America

    X
  • Cliona Molony equal contributor,

    equal contributor Contributed equally to this work with: Eric E Schadt, Cliona Molony, Eugene Chudin

    Affiliation: Rosetta Inpharmatics, Seattle, Washington, United States of America

    X
  • Eugene Chudin equal contributor,

    equal contributor Contributed equally to this work with: Eric E Schadt, Cliona Molony, Eugene Chudin

    Affiliation: Rosetta Inpharmatics, Seattle, Washington, United States of America

    X
  • Ke Hao,

    Affiliation: Rosetta Inpharmatics, Seattle, Washington, United States of America

    X
  • Xia Yang,

    Affiliation: Rosetta Inpharmatics, Seattle, Washington, United States of America

    X
  • Pek Y Lum,

    Affiliation: Rosetta Inpharmatics, Seattle, Washington, United States of America

    X
  • Andrew Kasarskis,

    Affiliation: Rosetta Inpharmatics, Seattle, Washington, United States of America

    X
  • Bin Zhang,

    Affiliation: Rosetta Inpharmatics, Seattle, Washington, United States of America

    X
  • Susanna Wang,

    Affiliation: Rosetta Inpharmatics, Seattle, Washington, United States of America

    X
  • Christine Suver,

    Affiliation: Rosetta Inpharmatics, Seattle, Washington, United States of America

    X
  • Jun Zhu,

    Affiliation: Rosetta Inpharmatics, Seattle, Washington, United States of America

    X
  • Joshua Millstein,

    Affiliation: Rosetta Inpharmatics, Seattle, Washington, United States of America

    X
  • Solveig Sieberts,

    Affiliation: Rosetta Inpharmatics, Seattle, Washington, United States of America

    X
  • John Lamb,

    Affiliation: Rosetta Inpharmatics, Seattle, Washington, United States of America

    X
  • Debraj GuhaThakurta,

    Affiliation: Rosetta Inpharmatics, Seattle, Washington, United States of America

    X
  • Jonathan Derry,

    Affiliation: Rosetta Inpharmatics, Seattle, Washington, United States of America

    X
  • John D Storey,

    Affiliations: Rosetta Inpharmatics, Seattle, Washington, United States of America, Department of Biostatistics, University of Washington, Seattle, Washington, United States of America, Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

    X
  • Iliana Avila-Campillo,

    Affiliation: Rosetta Inpharmatics, Seattle, Washington, United States of America

    X
  • Mark J Kruger,

    Affiliation: Rosetta Inpharmatics, Seattle, Washington, United States of America

    X
  • Jason M Johnson,

    Affiliation: Rosetta Inpharmatics, Seattle, Washington, United States of America

    X
  • Carol A Rohl,

    Affiliation: Rosetta Inpharmatics, Seattle, Washington, United States of America

    X
  • Atila van Nas,

    Affiliation: Department of Human Genetics, University of California Los Angeles, Los Angeles, California, United States of America

    X
  • Margarete Mehrabian,

    Affiliations: Department of Microbiology, Molecular Genetics, and Immunology, University of California Los Angeles, Los Angeles, California, United States of America, Department of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

    X
  • Thomas A Drake,

    Affiliation: Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California, United States of America

    X
  • Aldons J Lusis,

    Affiliations: Department of Microbiology, Molecular Genetics, and Immunology, University of California Los Angeles, Los Angeles, California, United States of America, Department of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, Department of Human Genetics, University of California Los Angeles, Los Angeles, California, United States of America

    X
  • Ryan C Smith,

    Affiliation: Rosetta Inpharmatics, Seattle, Washington, United States of America

    X
  • F. Peter Guengerich,

    Affiliations: Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Center of Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

    X
  • Stephen C Strom,

    Affiliation: Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

    X
  • Erin Schuetz,

    Affiliation: Department of Pharmaceutical Sciences, Saint Jude Children's Research Hospital, Memphis, Tennessee, United States of America

    X
  • Thomas H Rushmore,

    Affiliation: Drug Metabolism, Merck and Company, West Point, Pennsylvania, United States of America

    X
  • Roger Ulrich

    Affiliation: Rosetta Inpharmatics, Seattle, Washington, United States of America

    X
  • Published: May 06, 2008
  • DOI: 10.1371/journal.pbio.0060107

About the Authors

Eric E Schadt, Cliona Molony, Eugene Chudin, Ke Hao, Xia Yang, Pek Y Lum, Andrew Kasarskis, Bin Zhang, Susanna Wang, Christine Suver, Jun Zhu, Joshua Millstein, Solveig Sieberts, John Lamb, Debraj GuhaThakurta, Jonathan Derry, John D Storey, Iliana Avila-Campillo, Mark J Kruger, Jason M Johnson, Carol A Rohl, Ryan C Smith, Roger Ulrich
Rosetta Inpharmatics, Seattle, Washington, United States of America
John D Storey
Department of Biostatistics, University of Washington, Seattle, Washington, United States of America
John D Storey
Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America
Margarete Mehrabian, Aldons J Lusis
Department of Microbiology, Molecular Genetics, and Immunology, University of California Los Angeles, Los Angeles, California, United States of America
Margarete Mehrabian, Aldons J Lusis
Department of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
Atila van Nas, Aldons J Lusis
Department of Human Genetics, University of California Los Angeles, Los Angeles, California, United States of America
Thomas A Drake
Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California, United States of America
F. Peter Guengerich
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
F. Peter Guengerich
Center of Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
Stephen C Strom
Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
Erin Schuetz
Department of Pharmaceutical Sciences, Saint Jude Children's Research Hospital, Memphis, Tennessee, United States of America
Thomas H Rushmore
Drug Metabolism, Merck and Company, West Point, Pennsylvania, United States of America

Corresponding Author

Email: eric_schadt@merck.com

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

EES, CM, AK, JL, FG, SCS, ES, THR, RU conceived and designed the experiments. EES, CM, AK, CS, DG, AVN, MM, TAD, AJL, RCS, RU performed the experiments. EES, CM, EC, KH, XY, PKL, BZ, SW, JZ, JM, SKS, DG, JD, JS, RCS analyzed the data. EES, CM, EC, KH, BZ, CS, JZ, JM, SKS, IA-C, MK, JMJ, CR, MM, TAD, AJL, FG, SCS, ES, THR, RU contributed reagents/materials/analysis tools. EES, CM, EC, KH, XY, PKL, AK, BZ, SW, JZ, JM, SKS wrote the paper.