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Research Article

A Putative Cation Channel, NCA-1, and a Novel Protein, UNC-80, Transmit Neuronal Activity in C. elegans

  • Edward Yeh equal contributor,

    equal contributor Contributed equally to this work with: Edward Yeh, Sharon Ng, Mi Zhang

    Affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

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  • Sharon Ng equal contributor,

    equal contributor Contributed equally to this work with: Edward Yeh, Sharon Ng, Mi Zhang

    Affiliations: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

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  • Mi Zhang equal contributor,

    equal contributor Contributed equally to this work with: Edward Yeh, Sharon Ng, Mi Zhang

    Affiliation: Division of Biology, University of California San Diego, San Diego, California, United States of America

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  • Magali Bouhours,

    Affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

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  • Ying Wang,

    Affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

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  • Min Wang,

    Affiliation: Department of Neuroscience, Centre for Addiction and Mental Health, Clarke Division, University of Toronto, Toronto, Ontario, Canada

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  • Wesley Hung,

    Affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

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  • Kyota Aoyagi,

    Affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

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  • Katya Melnik-Martinez,

    Affiliation: Division of Biology, University of California San Diego, San Diego, California, United States of America

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  • Michelle Li,

    Affiliations: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

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  • Fang Liu,

    Affiliation: Department of Neuroscience, Centre for Addiction and Mental Health, Clarke Division, University of Toronto, Toronto, Ontario, Canada

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  • William R Schafer,

    Affiliations: Division of Biology, University of California San Diego, San Diego, California, United States of America, Cell Biology Division, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom

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  • Mei Zhen mail

    To whom correspondence should be addressed. E-mail: zhen@mshri.on.ca

    Affiliations: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

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  • Published: March 11, 2008
  • DOI: 10.1371/journal.pbio.0060055

About the Authors

Edward Yeh, Sharon Ng, Magali Bouhours, Ying Wang, Wesley Hung, Kyota Aoyagi, Michelle Li, Mei Zhen
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
Sharon Ng, Michelle Li, Mei Zhen
Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
Mi Zhang, Katya Melnik-Martinez, William R Schafer
Division of Biology, University of California San Diego, San Diego, California, United States of America
Min Wang, Fang Liu
Department of Neuroscience, Centre for Addiction and Mental Health, Clarke Division, University of Toronto, Toronto, Ontario, Canada
William R Schafer
Cell Biology Division, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom

Corresponding Author

Email: zhen@mshri.on.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

E. Yeh conceived and designed the experiments, performed the experiments, and analyzed the data. S. Ng and M. Zhang performed the experiments, analyzed the data, and contributed reagents/materials/analysis tools. M. Bouhours performed the experiments, analyzed the data, and wrote the paper. Y. Wang, K. Melnick-Martinez, and M. Li performed the experiments. M. Wang, W. Hung, and K. Aoyagi performed the experiments and analyzed the data. F. Liu conceived and designed the experiments. W. R. Schafer conceived and designed the experiments and wrote the paper. M. Zhen conceived and designed the experiments, performed the experiments, analyzed the data, and wrote the paper.