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Research Article

Insights into Mad2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric Mad2 Dimer

  • Maojun Yang,

    Affiliation: Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Bing Li,

    Affiliation: Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Chyong-Jy Liu,

    Affiliation: Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Diana R Tomchick,

    Affiliation: Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Mischa Machius,

    Affiliation: Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Josep Rizo,

    Affiliations: Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Hongtao Yu mail,

    To whom correspondence should be addressed. E-mail: hongtao.yu@utsouthwestern.edu (HY); xuelian.luo@utsouthwestern.edu (XL)

    Affiliation: Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Xuelian Luo mail

    To whom correspondence should be addressed. E-mail: hongtao.yu@utsouthwestern.edu (HY); xuelian.luo@utsouthwestern.edu (XL)

    Affiliation: Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Published: March 04, 2008
  • DOI: 10.1371/journal.pbio.0060050

About the Authors

Maojun Yang, Bing Li, Chyong-Jy Liu, Josep Rizo, Hongtao Yu, Xuelian Luo
Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
Diana R Tomchick, Mischa Machius, Josep Rizo
Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

JR, HY, and XL conceived and designed the experiments. MY, BL, CJL, DRT, MM, and XL performed the experiments. MY, DRT, MM, JR, HY, and XL analyzed the data. HY and XL wrote the paper.