Advertisement
Research Article

Genetic Deficiency of Glycogen Synthase Kinase-3β Corrects Diabetes in Mouse Models of Insulin Resistance

  • Katsuya Tanabe,

    Affiliation: Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Zhonghao Liu,

    Affiliation: Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Satish Patel,

    Affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

    X
  • Bradley W Doble,

    Affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

    X
  • Lin Li,

    Affiliation: Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Corentin Cras-Méneur,

    Affiliation: Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Sara C Martinez,

    Affiliation: Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Cris M Welling,

    Affiliation: Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Morris F White,

    Affiliation: Howard Hughes Medical Institute, Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Ernesto Bernal-Mizrachi,

    Affiliation: Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • James R Woodgett,

    Affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

    X
  • M. Alan Permutt mail

    To whom correspondence should be addressed. E-mail: apermutt@im.wustl.edu

    Affiliation: Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Published: February 19, 2008
  • DOI: 10.1371/journal.pbio.0060037

About the Authors

Katsuya Tanabe, Zhonghao Liu, Lin Li, Corentin Cras-Méneur, Sara C Martinez, Cris M Welling, Ernesto Bernal-Mizrachi, M. Alan Permutt
Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St. Louis, Missouri, United States of America
Satish Patel, Bradley W Doble, James R Woodgett
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
Morris F White
Howard Hughes Medical Institute, Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Corresponding Author

Email: apermutt@im.wustl.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

KT conceived, designed, and performed the experiments, analyzed the data, and wrote the paper. ZL and SCM performed experiments and analyzed data. SP and BWD performed experiments and contributed reagents/materials/analysis tools. LL and CMW performed experiments. CCM conceived and designed the experiments and wrote the paper. MFW and JRW contributed reagents/materials/analysis tools. EBM conceived and designed the experiments. MAP conceived, designed, and analyzed the data, and supervised the writing of the paper.