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Research Article

Mutation of RNA Pol III Subunit rpc2/polr3b Leads to Deficiency of Subunit Rpc11 and Disrupts Zebrafish Digestive Development

  • Nelson S Yee equal contributor,

    equal contributor Contributed equally to this work with: Nelson S Yee, Weilong Gong

    Affiliation: Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    ¤a Current address: Department of Internal Medicine, University of Iowa, Carver College of Medicine, Iowa City, Iowa, United States of America

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  • Weilong Gong equal contributor,

    equal contributor Contributed equally to this work with: Nelson S Yee, Weilong Gong

    Affiliation: Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    X
  • Ying Huang,

    Affiliation: National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America

    ¤b Current address: College of Life Sciences, Nanjing Normal University, Nanjing, Peoples Republic of China

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  • Kristin Lorent,

    Affiliation: Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    X
  • Amy C Dolan,

    Affiliation: Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    X
  • Richard J Maraia,

    Affiliation: National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Michael Pack mail

    To whom correspondence should be addressed. E-mail: mpack@mail.med.upenn.edu

    Affiliations: Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Published: November 27, 2007
  • DOI: 10.1371/journal.pbio.0050312

About the Authors

Nelson S Yee, Weilong Gong, Kristin Lorent, Amy C Dolan, Michael Pack
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
Ying Huang, Richard J Maraia
National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
Michael Pack
Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Corresponding Author

Email: mpack@mail.med.upenn.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

NSY, WG, YH, KL, RJM and MP conceived and designed the experiments and analyzed the data. NSY, WG, YH, KL, and ACD performed the experiments. RJM and MP wrote the paper.