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Research Article

Self-Organization in High-Density Bacterial Colonies: Efficient Crowd Control

  • HoJung Cho equal contributor,

    equal contributor Contributed equally to this work with: HoJung Cho, Henrik Jönsson

    Affiliation: Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, Maryland, United States of America

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  • Henrik Jönsson equal contributor,

    equal contributor Contributed equally to this work with: HoJung Cho, Henrik Jönsson

    Affiliation: Department of Theoretical Physics, Lund University, Lund, Sweden

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  • Kyle Campbell,

    Affiliation: Department of Physics, University of California San Diego, La Jolla, California, United States of America

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  • Pontus Melke,

    Affiliation: Department of Theoretical Physics, Lund University, Lund, Sweden

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  • Joshua W Williams,

    Affiliation: Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America

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  • Bruno Jedynak,

    Affiliation: Center for Imaging Science, The Johns Hopkins University, Baltimore, Maryland, United States of America

    X
  • Ann M Stevens,

    Affiliation: Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America

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  • Alex Groisman mail,

    To whom correspondence should be addressed. E-mail: alev@jhu.edu (AL), agroisman@ucsd.edu (AG)

    Affiliation: Department of Physics, University of California San Diego, La Jolla, California, United States of America

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  • Andre Levchenko mail

    To whom correspondence should be addressed. E-mail: alev@jhu.edu (AL), agroisman@ucsd.edu (AG)

    Affiliation: Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, Maryland, United States of America

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  • Published: October 30, 2007
  • DOI: 10.1371/journal.pbio.0050302

About the Authors

HoJung Cho, Andre Levchenko
Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, Maryland, United States of America
Henrik Jönsson, Pontus Melke
Department of Theoretical Physics, Lund University, Lund, Sweden
Kyle Campbell, Alex Groisman
Department of Physics, University of California San Diego, La Jolla, California, United States of America
Joshua W Williams, Ann M Stevens
Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America
Bruno Jedynak
Center for Imaging Science, The Johns Hopkins University, Baltimore, Maryland, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

HC, HJ, AG, and AL designed research. HC, HJ, PM, and AL performed the experiments and simulations. KC, AL and AG designed and fabricated the microfluidic devices. JWW, BJ, and AMS contributed new reagents/analysis tools. HC, HJ, PM, and AL analyzed data. HC, HJ, PM, AG, and AL wrote the paper.