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Research Article

Characterization of Sleep in Zebrafish and Insomnia in Hypocretin Receptor Mutants

  • Tohei Yokogawa,

    Affiliation: Howard Hughes Medical Institute, Stanford University, Palo Alto, California, United States of America

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  • Wilfredo Marin,

    Affiliation: Howard Hughes Medical Institute, Stanford University, Palo Alto, California, United States of America

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  • Juliette Faraco,

    Affiliation: Stanford Center for Narcolepsy, Stanford University, Palo Alto, California, United States of America

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  • Guillaume Pézeron,

    Affiliations: Ecole Normale Supérieure, Paris, France, INSERM Unité 784, Paris, France

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  • Lior Appelbaum,

    Affiliation: Howard Hughes Medical Institute, Stanford University, Palo Alto, California, United States of America

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  • Jian Zhang,

    Affiliation: Stanford Center for Narcolepsy, Stanford University, Palo Alto, California, United States of America

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  • Frédéric Rosa,

    Affiliations: Ecole Normale Supérieure, Paris, France, INSERM Unité 784, Paris, France

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  • Philippe Mourrain,

    Affiliation: Stanford Center for Narcolepsy, Stanford University, Palo Alto, California, United States of America

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  • Emmanuel Mignot mail

    To whom correspondence should be addressed. E-mail: mignot@stanford.edu

    Affiliations: Howard Hughes Medical Institute, Stanford University, Palo Alto, California, United States of America, Stanford Center for Narcolepsy, Stanford University, Palo Alto, California, United States of America

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  • Published: October 16, 2007
  • DOI: 10.1371/journal.pbio.0050277

About the Authors

Tohei Yokogawa, Wilfredo Marin, Lior Appelbaum, Emmanuel Mignot
Howard Hughes Medical Institute, Stanford University, Palo Alto, California, United States of America
Juliette Faraco, Jian Zhang, Philippe Mourrain, Emmanuel Mignot
Stanford Center for Narcolepsy, Stanford University, Palo Alto, California, United States of America
Guillaume Pézeron, Frédéric Rosa
Ecole Normale Supérieure, Paris, France
Guillaume Pézeron, Frédéric Rosa
INSERM Unité 784, Paris, France

Corresponding Author

Email: mignot@stanford.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

TY, WM, FR, PM, and EM conceived and designed the experiments. TY, WM, JF, GP, LA, and PM performed the experiments. TY, JF, JZ, PM, and EM analyzed the data. TY, GP, JZ, FR, PM, and EM contributed reagents/materials/analysis tools. TY, JF, PM, and EM wrote the paper. PM and EM contributed equally to the direction of this work.