Advertisement
Research Article

Assessing Tumor Progression Factors by Somatic Gene Transfer into a Mouse Model: Bcl-xL Promotes Islet Tumor Cell Invasion

  • Yi-Chieh Nancy Du mail,

    To whom correspondence should be addressed. E-mail: duy@mskcc.org

    Affiliation: Program in Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

    X
  • Brian C Lewis,

    Affiliation: Program in Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

    ยค Current address: University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

    X
  • Douglas Hanahan,

    Affiliation: Department of Biochemistry, University of California San Francisco, San Francisco, California, United States of America

    X
  • Harold Varmus

    Affiliation: Program in Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

    X
  • Published: October 16, 2007
  • DOI: 10.1371/journal.pbio.0050276

About the Authors

Yi-Chieh Nancy Du, Brian C Lewis, Harold Varmus
Program in Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
Douglas Hanahan
Department of Biochemistry, University of California San Francisco, San Francisco, California, United States of America

Corresponding Author

Email: duy@mskcc.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

YND and HV designed the experiments. BCL generated RIP-tva transgenic mice and contributed to the general strategy. DH contributed to the general strategy and provided RIP-Tag transgenic mice, protocols, and advice. YND performed the research. YND wrote the paper with assistance from HV, and BCL and DH reviewed and helped to edit the paper.