Advertisement
Research Article

Genetic Dissection of Behavioural and Autonomic Effects of Δ9-Tetrahydrocannabinol in Mice

  • Krisztina Monory,

    Affiliations: Department of Physiological Chemistry, Johannes Gutenberg University Mainz, Mainz, Germany, Max Planck Institute of Psychiatry, Munich, Germany

    X
  • Heike Blaudzun,

    Affiliation: Max Planck Institute of Psychiatry, Munich, Germany

    X
  • Federico Massa,

    Affiliations: Department of Physiological Chemistry, Johannes Gutenberg University Mainz, Mainz, Germany, Max Planck Institute of Psychiatry, Munich, Germany

    X
  • Nadine Kaiser,

    Affiliation: Department of Physiological Chemistry, Johannes Gutenberg University Mainz, Mainz, Germany

    X
  • Thomas Lemberger,

    Affiliation: Department of Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg, Germany

    X
  • Günther Schütz,

    Affiliation: Department of Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg, Germany

    X
  • Carsten T Wotjak,

    Affiliation: Max Planck Institute of Psychiatry, Munich, Germany

    X
  • Beat Lutz mail,

    To whom correspondence should be addressed. E-mail: marsicano@bordeaux.inserm.fr (GM); blutz@uni-mainz.de (BL)

    Affiliations: Department of Physiological Chemistry, Johannes Gutenberg University Mainz, Mainz, Germany, Max Planck Institute of Psychiatry, Munich, Germany

    X
  • Giovanni Marsicano mail

    To whom correspondence should be addressed. E-mail: marsicano@bordeaux.inserm.fr (GM); blutz@uni-mainz.de (BL)

    Affiliations: Department of Physiological Chemistry, Johannes Gutenberg University Mainz, Mainz, Germany, U862 Institute F. Magendie, University Bordeaux 2, INSERM, Avenir Group 4, Bordeaux, France

    X
  • Published: October 09, 2007
  • DOI: 10.1371/journal.pbio.0050269

About the Authors

Krisztina Monory, Federico Massa, Nadine Kaiser, Beat Lutz, Giovanni Marsicano
Department of Physiological Chemistry, Johannes Gutenberg University Mainz, Mainz, Germany
Krisztina Monory, Heike Blaudzun, Federico Massa, Carsten T Wotjak, Beat Lutz
Max Planck Institute of Psychiatry, Munich, Germany
Thomas Lemberger, Günther Schütz
Department of Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg, Germany
Giovanni Marsicano
U862 Institute F. Magendie, University Bordeaux 2, INSERM, Avenir Group 4, Bordeaux, France

Corresponding Authors

Competing Interests

The authors declare that they have no financial, personal, or professional interests that could be construed to have influenced the present paper.

Author Contributions

KM participated in the design of the experiments, performed the behavioural tests, part of the ISH analysis, and wrote the manuscript. HB performed part of the ISH analysis. FM contributed to the design of the experiments and to the writing. NK participated to behavioural experiments. TL and GS generated the D1-Cre mice and contributed to the writing of the manuscript. CTW participated to the design of experiments, provided equipment and expertise for behavioural analysis, participated in the data analysis and in the writing of the manuscript. BL and GM equally supervised the entire work, generated the conditional mutants, wrote the manuscript, and share senior authorship.