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Research Article

Spatial Learning Depends on Both the Addition and Removal of New Hippocampal Neurons

  • David Dupret,

    Affiliations: INSERM U862, Bordeaux Neuroscience Research Center, Bordeaux, France, University of Bordeaux 2, Bordeaux, France

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  • Annabelle Fabre,

    Affiliations: INSERM U862, Bordeaux Neuroscience Research Center, Bordeaux, France, University of Bordeaux 2, Bordeaux, France

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  • Màtè Dàniel Döbrössy,

    Affiliations: INSERM U862, Bordeaux Neuroscience Research Center, Bordeaux, France, University of Bordeaux 2, Bordeaux, France

    ¤ Current address: School of Biosciences, Cardiff University, Cardiff, United Kingdom

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  • Aude Panatier,

    Affiliations: INSERM U862, Bordeaux Neuroscience Research Center, Bordeaux, France, University of Bordeaux 2, Bordeaux, France

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  • José Julio Rodríguez,

    Affiliation: The University of Manchester, Manchester, United Kingdom

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  • Stéphanie Lamarque,

    Affiliations: INSERM U862, Bordeaux Neuroscience Research Center, Bordeaux, France, University of Bordeaux 2, Bordeaux, France

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  • Valerie Lemaire,

    Affiliations: INSERM U862, Bordeaux Neuroscience Research Center, Bordeaux, France, University of Bordeaux 2, Bordeaux, France

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  • Stephane H. R Oliet,

    Affiliations: INSERM U862, Bordeaux Neuroscience Research Center, Bordeaux, France, University of Bordeaux 2, Bordeaux, France

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  • Pier-Vincenzo Piazza equal contributor,

    equal contributor Contributed equally to this work with: Pier-Vincenzo Piazza, Djoher Nora Abrous

    Affiliations: INSERM U862, Bordeaux Neuroscience Research Center, Bordeaux, France, University of Bordeaux 2, Bordeaux, France

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  • Djoher Nora Abrous equal contributor mail

    equal contributor Contributed equally to this work with: Pier-Vincenzo Piazza, Djoher Nora Abrous

    To whom correspondence should be addressed. E-mail: abrous@bordeaux.inserm.fr

    Affiliations: INSERM U862, Bordeaux Neuroscience Research Center, Bordeaux, France, University of Bordeaux 2, Bordeaux, France

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  • Published: August 07, 2007
  • DOI: 10.1371/journal.pbio.0050214

About the Authors

David Dupret, Annabelle Fabre, Màtè Dàniel Döbrössy, Aude Panatier, Stéphanie Lamarque, Valerie Lemaire, Stephane H. R Oliet, Pier-Vincenzo Piazza, Djoher Nora Abrous
INSERM U862, Bordeaux Neuroscience Research Center, Bordeaux, France
David Dupret, Annabelle Fabre, Màtè Dàniel Döbrössy, Aude Panatier, Stéphanie Lamarque, Valerie Lemaire, Stephane H. R Oliet, Pier-Vincenzo Piazza, Djoher Nora Abrous
University of Bordeaux 2, Bordeaux, France
José Julio Rodríguez
The University of Manchester, Manchester, United Kingdom

Corresponding Author

Email: abrous@bordeaux.inserm.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

DD is the lead author. He contributed to the concept and design of the experiments, and performed the experiments, analyzed the data, and revised the manuscript. AF performed zVAD stereotaxic injections, behavior experiments, and cell counting (batches 9 and 11). MDD contributed to the first experiment (batch 1). JJR and SL participated in immunohistochemistry. VL performed a behavioral experiment (batch 2). AP and SHRO performed electrophysiology recordings (batch 10). PVP contributed to the concept, designed some of the experiments, interpreted some of the data, and wrote the manuscript. DNA contributed to the concept, designed the experiments, interpreted the data, wrote the manuscript, and provided financial support.