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Research Article

An Integrated Gene Regulatory Network Controls Stem Cell Proliferation in Teeth

  • Xiu-Ping Wang equal contributor,

    equal contributor Contributed equally to this work with: Xiu-Ping Wang, Marika Suomalainen

    Affiliations: Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland, Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Marika Suomalainen equal contributor,

    equal contributor Contributed equally to this work with: Xiu-Ping Wang, Marika Suomalainen

    Affiliation: Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland

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  • Szabolcs Felszeghy,

    Affiliation: Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland

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  • Laura C Zelarayan,

    Affiliation: Center for Molecular Neurobiology Hamburg, University of Hamburg, Hamburg, Germany

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  • Maria T Alonso,

    Affiliations: Center for Molecular Neurobiology Hamburg, University of Hamburg, Hamburg, Germany, Institute for Biology and Molecular Genetics, Superior Research Council and University of Valladolid, Valladolid, Spain

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  • Maksim V Plikus,

    Affiliation: Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Richard L Maas,

    Affiliation: Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Cheng-Ming Chuong,

    Affiliation: Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Thomas Schimmang,

    Affiliations: Center for Molecular Neurobiology Hamburg, University of Hamburg, Hamburg, Germany, Institute for Biology and Molecular Genetics, Superior Research Council and University of Valladolid, Valladolid, Spain

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  • Irma Thesleff mail

    To whom correspondence should be addressed. E-mail: irma.thesleff@helsinki.fi

    Affiliation: Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland

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  • Published: June 12, 2007
  • DOI: 10.1371/journal.pbio.0050159

About the Authors

Xiu-Ping Wang, Marika Suomalainen, Szabolcs Felszeghy, Irma Thesleff
Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
Xiu-Ping Wang, Richard L Maas
Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
Laura C Zelarayan, Maria T Alonso, Thomas Schimmang
Center for Molecular Neurobiology Hamburg, University of Hamburg, Hamburg, Germany
Maria T Alonso, Thomas Schimmang
Institute for Biology and Molecular Genetics, Superior Research Council and University of Valladolid, Valladolid, Spain
Maksim V Plikus, Cheng-Ming Chuong
Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

Corresponding Author

Email: irma.thesleff@helsinki.fi

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

XPW, MS, SF, LCZ, MTA, MVP, CMC, TS, and IT conceived and designed the experiments. XPW, MS, SF, LCZ, MTA, and MVP performed the experiments. XPW, MS, SF, LCZ, MVP, RLM, CMC, TS, and IT analyzed the data. XPW, MS, SF, RLM, CMC, TS, and IT wrote the paper.