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Research Article

DNA-Dependent Protein Kinase Inhibits AID-Induced Antibody Gene Conversion

  • Adam J. L Cook,

    Affiliation: Centenary Institute and University of Sydney Faculty of Medicine, Sydney, New South Wales, Australia

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  • Joanna M Raftery,

    Affiliation: Centenary Institute and University of Sydney Faculty of Medicine, Sydney, New South Wales, Australia

    ¤ Current address: Institute for Neuromuscular Research, Children's Hospital at Westmead, Sydney, New South Wales, Australia

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  • K. K. Edwin Lau,

    Affiliation: Centenary Institute and University of Sydney Faculty of Medicine, Sydney, New South Wales, Australia

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  • Andrew Jessup,

    Affiliation: Centenary Institute and University of Sydney Faculty of Medicine, Sydney, New South Wales, Australia

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  • Reuben S Harris,

    Affiliations: Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota, United States of America, Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, United States of America

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  • Shunichi Takeda,

    Affiliation: Department of Radiation Genetics, Kyoto University School of Medicine, Kyoto, Japan

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  • Christopher J Jolly mail

    To whom correspondence should be addressed. E-mail: c.jolly@centenary.org.au

    Affiliation: Centenary Institute and University of Sydney Faculty of Medicine, Sydney, New South Wales, Australia

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  • Published: March 13, 2007
  • DOI: 10.1371/journal.pbio.0050080

About the Authors

Adam J. L Cook, Joanna M Raftery, K. K. Edwin Lau, Andrew Jessup, Christopher J Jolly
Centenary Institute and University of Sydney Faculty of Medicine, Sydney, New South Wales, Australia
Reuben S Harris
Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota, United States of America
Reuben S Harris
Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, United States of America
Shunichi Takeda
Department of Radiation Genetics, Kyoto University School of Medicine, Kyoto, Japan

Corresponding Author

Email: c.jolly@centenary.org.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

CJJ conceived and designed the experiments. AJLC, JMR, KKEL, AJ, and CJJ performed the experiments. AJLC and CJJ analyzed the data. RSH and ST contributed reagents/materials/analysis tools. AJLC and CJJ wrote the paper.