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Research Article

Epigenetic Control of the foxp3 Locus in Regulatory T Cells

  • Stefan Floess equal contributor,

    equal contributor Contributed equally to this work with: Stefan Floess, Jennifer Freyer, Christiane Siewert

    Affiliation: Experimentelle Rheumatologie, Charité Universitaetsmedizin Berlin, Berlin, Germany

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  • Jennifer Freyer equal contributor,

    equal contributor Contributed equally to this work with: Stefan Floess, Jennifer Freyer, Christiane Siewert

    Affiliation: Experimentelle Rheumatologie, Charité Universitaetsmedizin Berlin, Berlin, Germany

    X
  • Christiane Siewert equal contributor,

    equal contributor Contributed equally to this work with: Stefan Floess, Jennifer Freyer, Christiane Siewert

    Affiliation: Experimentelle Rheumatologie, Charité Universitaetsmedizin Berlin, Berlin, Germany

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  • Udo Baron,

    Affiliation: Epiontis, Berlin, Germany

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  • Sven Olek,

    Affiliation: Epiontis, Berlin, Germany

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  • Julia Polansky,

    Affiliation: Experimentelle Rheumatologie, Charité Universitaetsmedizin Berlin, Berlin, Germany

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  • Kerstin Schlawe,

    Affiliation: Experimentelle Rheumatologie, Charité Universitaetsmedizin Berlin, Berlin, Germany

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  • Hyun-Dong Chang,

    Affiliation: Deutsches Rheuma-Forschungszentrum, Berlin, Germany

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  • Tobias Bopp,

    Affiliation: Institut für Immunologie, Johannes-Gutenberg-Universität, Mainz, Germany

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  • Edgar Schmitt,

    Affiliation: Institut für Immunologie, Johannes-Gutenberg-Universität, Mainz, Germany

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  • Stefan Klein-Hessling,

    Affiliation: Abteilung für Molekulare Pathologie, Pathologisches Institut, Wuerzburg, Germany

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  • Edgar Serfling,

    Affiliation: Abteilung für Molekulare Pathologie, Pathologisches Institut, Wuerzburg, Germany

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  • Alf Hamann,

    Affiliation: Experimentelle Rheumatologie, Charité Universitaetsmedizin Berlin, Berlin, Germany

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  • Jochen Huehn mail

    To whom correspondence should be addressed. E-mail: Huehn@drfz.de

    Affiliation: Experimentelle Rheumatologie, Charité Universitaetsmedizin Berlin, Berlin, Germany

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  • Published: January 30, 2007
  • DOI: 10.1371/journal.pbio.0050038

About the Authors

Stefan Floess, Jennifer Freyer, Christiane Siewert, Julia Polansky, Kerstin Schlawe, Alf Hamann, Jochen Huehn
Experimentelle Rheumatologie, Charité Universitaetsmedizin Berlin, Berlin, Germany
Udo Baron, Sven Olek
Epiontis, Berlin, Germany
Hyun-Dong Chang
Deutsches Rheuma-Forschungszentrum, Berlin, Germany
Tobias Bopp, Edgar Schmitt
Institut für Immunologie, Johannes-Gutenberg-Universität, Mainz, Germany
Stefan Klein-Hessling, Edgar Serfling
Abteilung für Molekulare Pathologie, Pathologisches Institut, Wuerzburg, Germany

Corresponding Author

Email: Huehn@drfz.de

Competing Interests

We herewith state a competing financial interest for the authors S. Olek and U. Baron, who are a founder and an employee of the company Epiontis, respectively.

Author Contributions

S. Floess, A. Hamann, and J. Huehn conceived and designed the experiments. S. Floess, J. Freyer, C. Siewert, U. Baron, J. Polansky, K. Schlawe, H. D. Chang, T. Bopp, and S. Klein-Hessling performed the experiments. S. Floess, U. Baron, S. Olek, E. Schmitt, E. Serfling, A. Hamann, and J. Huehn analyzed the data. S. Olek contributed reagents/materials/analysis tools. A. Hamann and J. Huehn wrote the paper.