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Research Article

The RNA-Binding Protein KSRP Promotes Decay of β-Catenin mRNA and Is Inactivated by PI3K-AKT Signaling

  • Roberto Gherzi equal contributor mail,

    equal contributor Contributed equally to this work with: Roberto Gherzi, Paola Briata

    To whom correspondence should be addressed. E-mail: rgherzi@ucsd.edu

    Affiliation: Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy

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  • Michele Trabucchi,

    Affiliation: Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy

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  • Marco Ponassi,

    Affiliation: Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy

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  • Tina Ruggiero,

    Affiliation: Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy

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  • Giorgio Corte,

    Affiliations: Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy, Department of Biology, Oncology, and Genetics, University of Genova, Genova, Italy

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  • Christoph Moroni,

    Affiliation: Institute for Medical Microbiology, University of Basel, Basel, Switzerland

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  • Ching-Yi Chen,

    Affiliation: Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Khalid S Khabar,

    Affiliation: King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia

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  • Jens S Andersen,

    Affiliation: Center for Experimental Bioinformatics, University of Southern Denmark, Odense, Denmark

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  • Paola Briata equal contributor

    equal contributor Contributed equally to this work with: Roberto Gherzi, Paola Briata

    Affiliation: Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy

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  • Published: December 19, 2006
  • DOI: 10.1371/journal.pbio.0050005

About the Authors

Roberto Gherzi, Michele Trabucchi, Marco Ponassi, Tina Ruggiero, Giorgio Corte, Paola Briata
Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
Giorgio Corte
Department of Biology, Oncology, and Genetics, University of Genova, Genova, Italy
Christoph Moroni
Institute for Medical Microbiology, University of Basel, Basel, Switzerland
Ching-Yi Chen
Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
Khalid S Khabar
King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
Jens S Andersen
Center for Experimental Bioinformatics, University of Southern Denmark, Odense, Denmark

Corresponding Author

Email: rgherzi@ucsd.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

RG and PB conceived and designed the experiments. RG, MT, MP, TR, KSK, JSA, and PB performed the experiments. RG, MT, KSK, JSA, and PB analyzed the data. GC, CM, and CYC contributed reagents/materials/analysis tools. RG, MT, and PB wrote the paper.