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Research Article

Adaptation to ER Stress Is Mediated by Differential Stabilities of Pro-Survival and Pro-Apoptotic mRNAs and Proteins

  • D. Thomas Rutkowski,

    Affiliation: Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, Michigan, United States of America

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  • Stacey M Arnold,

    Affiliation: Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, Michigan, United States of America

    ¤ Current address: Johns Hopkins Medical Institute, Baltimore, Maryland, United States of America

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  • Corey N Miller,

    Affiliation: Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, Michigan, United States of America

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  • Jun Wu,

    Affiliation: Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, Michigan, United States of America

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  • Jack Li,

    Affiliation: Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, Michigan, United States of America

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  • Kathryn M Gunnison,

    Affiliation: Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, Michigan, United States of America

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  • Kazutoshi Mori,

    Affiliation: Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan

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  • Amir A. Sadighi Akha,

    Affiliation: Department of Pathology, University of Michigan Medical Center, Ann Arbor, Michigan, United States of America

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  • David Raden,

    Affiliation: Department of Chemical Engineering, University of Delaware, Newark, Delaware, United States of America

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  • Randal J Kaufman mail

    To whom correspondence should be addressed. E-mail: kaufmanr@umich.edu

    Affiliations: Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, Michigan, United States of America, Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, Michigan, United States of America, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, United States of America

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  • Published: November 07, 2006
  • DOI: 10.1371/journal.pbio.0040374

About the Authors

D. Thomas Rutkowski, Randal J Kaufman
Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, Michigan, United States of America
Stacey M Arnold, Corey N Miller, Jun Wu, Jack Li, Kathryn M Gunnison, Randal J Kaufman
Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, Michigan, United States of America
Kazutoshi Mori
Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan
Amir A. Sadighi Akha
Department of Pathology, University of Michigan Medical Center, Ann Arbor, Michigan, United States of America
David Raden
Department of Chemical Engineering, University of Delaware, Newark, Delaware, United States of America
Randal J Kaufman
Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, United States of America

Corresponding Author

Email: kaufmanr@umich.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

DTR conceived and designed the experiments. DTR, SMA, CNM, JW, JL, KMG, and AASA performed the experiments. DTR and RJK analyzed the data. KM contributed reagents/materials/analysis tools. DTR and RJK wrote the paper. DR constructed the mathematical model.