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Research Article

Ablation of PGC-1β Results in Defective Mitochondrial Activity, Thermogenesis, Hepatic Function, and Cardiac Performance

  • Christopher J Lelliott equal contributor,

    equal contributor Contributed equally to this work with: Christopher J Lelliott, Gema Medina-Gomez

    Affiliations: Department of Clinical Biochemistry, University of Cambridge, Cambridge, United Kingdom, AstraZeneca R&D, Mölndal, Sweden

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  • Gema Medina-Gomez equal contributor,

    equal contributor Contributed equally to this work with: Christopher J Lelliott, Gema Medina-Gomez

    Affiliation: Department of Clinical Biochemistry, University of Cambridge, Cambridge, United Kingdom

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  • Natasa Petrovic,

    Affiliation: The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden

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  • Adrienn Kis,

    Affiliation: Department of Clinical Biochemistry, University of Cambridge, Cambridge, United Kingdom

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  • Helena M Feldmann,

    Affiliation: The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden

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  • Mikael Bjursell,

    Affiliation: AstraZeneca R&D, Mölndal, Sweden

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  • Nadeene Parker,

    Affiliation: Department of Clinical Biochemistry, University of Cambridge, Cambridge, United Kingdom

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  • Keira Curtis,

    Affiliation: Department of Clinical Biochemistry, University of Cambridge, Cambridge, United Kingdom

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  • Mark Campbell,

    Affiliation: Department of Clinical Biochemistry, University of Cambridge, Cambridge, United Kingdom

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  • Ping Hu,

    Affiliation: Division of Cardiology, University of Utah, Salt Lake City, Utah, United States of America

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  • Dongfang Zhang,

    Affiliation: Division of Cardiology, University of Utah, Salt Lake City, Utah, United States of America

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  • Sheldon E Litwin,

    Affiliation: Division of Cardiology, University of Utah, Salt Lake City, Utah, United States of America

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  • Vlad G Zaha,

    Affiliation: Division of Endocrinology, Metabolism, and Diabetes and Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, Utah, United States of America

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  • Kimberly T Fountain,

    Affiliation: Division of Endocrinology, Metabolism, and Diabetes and Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, Utah, United States of America

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  • Sihem Boudina,

    Affiliation: Division of Endocrinology, Metabolism, and Diabetes and Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, Utah, United States of America

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  • Mercedes Jimenez-Linan,

    Affiliation: Department of Clinical Biochemistry, University of Cambridge, Cambridge, United Kingdom

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  • Margaret Blount,

    Affiliation: Department of Clinical Biochemistry, University of Cambridge, Cambridge, United Kingdom

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  • Miguel Lopez,

    Affiliation: Department of Clinical Biochemistry, University of Cambridge, Cambridge, United Kingdom

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  • Aline Meirhaeghe,

    Affiliation: INSERM, Institut Pasteur de Lille, Lille Cedex, France

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  • Mohammad Bohlooly-Y,

    Affiliation: AstraZeneca R&D, Mölndal, Sweden

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  • Leonard Storlien,

    Affiliation: AstraZeneca R&D, Mölndal, Sweden

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  • Maria Strömstedt,

    Affiliation: AstraZeneca R&D, Mölndal, Sweden

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  • Michael Snaith,

    Affiliation: AstraZeneca R&D, Mölndal, Sweden

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  • Matej Orešič,

    Affiliation: VTT Technical Research Centre of Finland, Espoo, Finland

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  • E. Dale Abel,

    Affiliation: Division of Endocrinology, Metabolism, and Diabetes and Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, Utah, United States of America

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  • Barbara Cannon,

    Affiliation: The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden

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  • Antonio Vidal-Puig mail

    To whom correspondence should be addressed. E-mail: ajv22@cam.ac.uk

    Affiliation: Department of Clinical Biochemistry, University of Cambridge, Cambridge, United Kingdom

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  • Published: November 07, 2006
  • DOI: 10.1371/journal.pbio.0040369

About the Authors

Christopher J Lelliott, Gema Medina-Gomez, Adrienn Kis, Nadeene Parker, Keira Curtis, Mark Campbell, Mercedes Jimenez-Linan, Margaret Blount, Miguel Lopez, Antonio Vidal-Puig
Department of Clinical Biochemistry, University of Cambridge, Cambridge, United Kingdom
Christopher J Lelliott, Mikael Bjursell, Mohammad Bohlooly-Y, Leonard Storlien, Maria Strömstedt, Michael Snaith
AstraZeneca R&D, Mölndal, Sweden
Natasa Petrovic, Helena M Feldmann, Barbara Cannon
The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden
Ping Hu, Dongfang Zhang, Sheldon E Litwin
Division of Cardiology, University of Utah, Salt Lake City, Utah, United States of America
Vlad G Zaha, Kimberly T Fountain, Sihem Boudina, E. Dale Abel
Division of Endocrinology, Metabolism, and Diabetes and Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, Utah, United States of America
Aline Meirhaeghe
INSERM, Institut Pasteur de Lille, Lille Cedex, France
Matej Orešič
VTT Technical Research Centre of Finland, Espoo, Finland

Corresponding Author

Email: ajv22@cam.ac.uk

Author Contributions

C. Lelliott, G. Medina-Gomez, M. Snaith, B. Cannon, and A. Vidal-Puig conceived and designed the experiments. C. Lelliott, G. Medina-Gomez, N. Petrovic, A. Kis, H. Feldmann, M. Bjursell, N. Parker, M. Campbell, P. Hu, D. Zhang, S. Litwin, V. Zaha, K. Fountain, S. Boudina, M. Jimenez-Linan, M. Blount, M. Lopez, A. Meirhaeghe, M. Bohlooly-Y, and M. Strömstedt performed the experiments. C. Lelliott, G. Medina-Gomez, N. Petrovic, A. Kis, H. Feldmann, N. Parker, K. Curtis, K. Fountain, S. Boudina, M. Jimenez-Linan, M. Blount, M. Orešič, E. Abel, B. Cannon, and A. Vidal-Puig analyzed the data. K. Curtis, M. Bohlooly-Y, M. Snaith, and M. Orešič contributed reagents/materials/analysis tools. C. Lelliott, G. Medina-Gomez, M. Snaith, E. Abel, B. Cannon, and A. Vidal-Puig wrote the paper.