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Research Article

The Liganding of Glycolipid Transfer Protein Is Controlled by Glycolipid Acyl Structure

  • Lucy Malinina equal contributor,

    equal contributor Contributed equally to this work with: Lucy Malinina, Margarita L Malakhova

    Affiliation: Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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  • Margarita L Malakhova equal contributor,

    equal contributor Contributed equally to this work with: Lucy Malinina, Margarita L Malakhova

    Affiliation: Hormel Institute, University of Minnesota, Austin, Minnesota, United States of America

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  • Alex T Kanack,

    Affiliation: Hormel Institute, University of Minnesota, Austin, Minnesota, United States of America

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  • Min Lu,

    Affiliation: Department of Biochemistry, Weill Medical College of Cornell University, New York, New York, United States of America

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  • Ruben Abagyan,

    Affiliation: Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America

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  • Rhoderick E Brown mail,

    To whom correspondence should be addressed. E-mail: reb@umn.edu (REB); pateld@mskcc.org (DJP)

    Affiliation: Hormel Institute, University of Minnesota, Austin, Minnesota, United States of America

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  • Dinshaw J Patel mail

    To whom correspondence should be addressed. E-mail: reb@umn.edu (REB); pateld@mskcc.org (DJP)

    Affiliation: Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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  • Published: October 24, 2006
  • DOI: 10.1371/journal.pbio.0040362

About the Authors

Lucy Malinina, Dinshaw J Patel
Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
Margarita L Malakhova, Alex T Kanack, Rhoderick E Brown
Hormel Institute, University of Minnesota, Austin, Minnesota, United States of America
Min Lu
Department of Biochemistry, Weill Medical College of Cornell University, New York, New York, United States of America
Ruben Abagyan
Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

LM, MLM, REB, and DJP conceived and designed the experiments. LM was responsible for x-ray data collection, analysis and structure determination. MLM was responsible for the biochemistry and crystallization, with biochemical assistance from ATK. ML was responsible for the ultracentrifugation experiments. RA was responsible for the ODA calculations. REB and DJP supervised and insured implementation of the project. LM, REB, and DJP wrote the paper with contributions from MLM, ML, and RA.