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Research Article

Uncoiling Mechanics of Escherichia coli Type I Fimbriae Are Optimized for Catch Bonds

  • Manu Forero,

    Affiliation: Department of Materials, Laboratory for Biologically Oriented Materials, ETH Zurich, Zurich, Switzerland

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  • Olga Yakovenko,

    Affiliation: Department of Bioengineering, University of Washington, Seattle, Washington, United States of America

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  • Evgeni V Sokurenko,

    Affiliation: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

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  • Wendy E Thomas mail,

    To whom correspondence should be addressed. E-mail: wendyt@u.washington.edu (WET); viola.vogel@mat.ethz.ch (VV)

    Affiliation: Department of Bioengineering, University of Washington, Seattle, Washington, United States of America

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  • Viola Vogel mail

    To whom correspondence should be addressed. E-mail: wendyt@u.washington.edu (WET); viola.vogel@mat.ethz.ch (VV)

    Affiliation: Department of Materials, Laboratory for Biologically Oriented Materials, ETH Zurich, Zurich, Switzerland

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  • Published: August 29, 2006
  • DOI: 10.1371/journal.pbio.0040298

About the Authors

Manu Forero, Viola Vogel
Department of Materials, Laboratory for Biologically Oriented Materials, ETH Zurich, Zurich, Switzerland
Olga Yakovenko, Wendy E Thomas
Department of Bioengineering, University of Washington, Seattle, Washington, United States of America
Evgeni V Sokurenko
Department of Microbiology, University of Washington, Seattle, Washington, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

MF, EVS, WET, and VV conceived and designed the experiments. OY performed the flow chamber experiments, and MF performed all other experiments. MF, WET, and VV analyzed the data. EVS and VV contributed reagents/materials/analysis tools. MF, EVS, WET, and VV wrote the paper.