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Research Article

Dorsoventral Patterning in Hemichordates: Insights into Early Chordate Evolution

  • Christopher J Lowe,

    Affiliation: Department of Organismal Biology and Anatomy, University of Chicago, Chicago, Illinois, United States of America

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  • Mark Terasaki,

    Affiliation: Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut, United States of America

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  • Michael Wu,

    Affiliation: Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America

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  • Robert M Freeman Jr.,

    Affiliation: Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Linda Runft,

    Affiliation: Department of Molecular, Cellular, and Developmental Biology, University of California Santa Barbara, Santa Barbara, California, United States of America

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  • Kristen Kwan,

    Affiliation: Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Saori Haigo,

    Affiliation: Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Jochanan Aronowicz,

    Affiliation: Department of Organismal Biology and Anatomy, University of Chicago, Chicago, Illinois, United States of America

    X
  • Eric Lander,

    Affiliations: Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Chris Gruber,

    Affiliation: Express Genomics, Frederick, Maryland, United States of America

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  • Mark Smith,

    Affiliation: Express Genomics, Frederick, Maryland, United States of America

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  • Marc Kirschner,

    Affiliation: Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • John Gerhart mail

    To whom correspondence should be addressed. E-mail: gerhart@socrates.berkeley.edu

    Affiliation: Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America

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  • Published: August 22, 2006
  • DOI: 10.1371/journal.pbio.0040291

About the Authors

Christopher J Lowe, Jochanan Aronowicz
Department of Organismal Biology and Anatomy, University of Chicago, Chicago, Illinois, United States of America
Mark Terasaki
Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut, United States of America
Michael Wu, John Gerhart
Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America
Robert M Freeman Jr., Kristen Kwan, Saori Haigo, Eric Lander, Marc Kirschner
Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America
Linda Runft
Department of Molecular, Cellular, and Developmental Biology, University of California Santa Barbara, Santa Barbara, California, United States of America
Eric Lander
Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
Eric Lander
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Chris Gruber, Mark Smith
Express Genomics, Frederick, Maryland, United States of America

Corresponding Author

Email: gerhart@socrates.berkeley.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

CJL, MK, and JG conceived and designed the experiments. CJL, MT, MW, LR, KK, SH, JA, MK, and JG performed the experiments. CJL, MK, and JG analyzed the data. CJL, RMF, EL, CG, and MS contributed reagents/materials/analysis tools. CJL, MK, and JG wrote the paper.