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Research Article

Role of the AP2 β-Appendage Hub in Recruiting Partners for Clathrin-Coated Vesicle Assembly

  • Eva M Schmid equal contributor,

    equal contributor Contributed equally to this work with: Eva M Schmid, Marijn G. J Ford

    Affiliation: Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom

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  • Marijn G. J Ford equal contributor,

    equal contributor Contributed equally to this work with: Eva M Schmid, Marijn G. J Ford

    Affiliation: Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom

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  • Anne Burtey,

    Affiliation: Department of Infectious Diseases, Institut Cochin, Paris, France

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  • Gerrit J. K Praefcke,

    Affiliation: Center for Molecular Medicine Cologne, Institute for Genetics, University of Cologne, Köln, Germany

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  • Sew-Yeu Peak-Chew,

    Affiliation: Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom

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  • Ian G Mills,

    Affiliation: The Oncology Department, University of Cambridge Hutchison/MRC Cancer Research Centre, Cambridge, United Kingdom

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  • Alexandre Benmerah,

    Affiliation: Department of Infectious Diseases, Institut Cochin, Paris, France

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  • Harvey T McMahon mail

    To whom correspondence should be addressed. E-mail: hmm@mrc-lmb.cam.ac.uk

    Affiliation: Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom

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  • Published: August 15, 2006
  • DOI: 10.1371/journal.pbio.0040262

About the Authors

Eva M Schmid, Marijn G. J Ford, Sew-Yeu Peak-Chew, Harvey T McMahon
Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom
Anne Burtey, Alexandre Benmerah
Department of Infectious Diseases, Institut Cochin, Paris, France
Gerrit J. K Praefcke
Center for Molecular Medicine Cologne, Institute for Genetics, University of Cologne, Köln, Germany
Ian G Mills
The Oncology Department, University of Cambridge Hutchison/MRC Cancer Research Centre, Cambridge, United Kingdom

Corresponding Author

Email: hmm@mrc-lmb.cam.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

EMS, MGJF, AB, and HTM conceived and designed the experiments. AB performed the cell biology, MGJF the crystallography, and EMS the majority of the in vitro studies along with GJKP, SYPC, and IGM. EMS and HTM wrote the paper.