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Research Article

X Chromosomes Alternate between Two States prior to Random X-Inactivation

  • Susanna Mlynarczyk-Evans,

    Affiliation: Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America

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  • Morgan Royce-Tolland,

    Affiliation: Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America

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  • Mary Kate Alexander,

    Affiliation: Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America

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  • Angela A Andersen,

    Affiliation: Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America

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  • Sundeep Kalantry,

    Affiliation: Department of Genetics and the Carolina Center for the Genome Sciences, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Joost Gribnau,

    Affiliation: Department of Cell Biology, Erasmus University Medical Center, Rotterdam, Netherlands

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  • Barbara Panning mail

    To whom correspondence should be addressed. E-mail: bpanning@biochem.ucsf.edu

    Affiliation: Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America

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  • Published: May 09, 2006
  • DOI: 10.1371/journal.pbio.0040159

About the Authors

Susanna Mlynarczyk-Evans, Morgan Royce-Tolland, Mary Kate Alexander, Angela A Andersen, Barbara Panning
Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
Sundeep Kalantry
Department of Genetics and the Carolina Center for the Genome Sciences, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America
Joost Gribnau
Department of Cell Biology, Erasmus University Medical Center, Rotterdam, Netherlands

Corresponding Author

Email: bpanning@biochem.ucsf.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

SME, MRT, MKA, and BP conceived and designed the experiments. SME, MRT, MKA, and AAA performed the experiments. SME, MRT, MKA, AAA, and BP analyzed the data. SK and JG contributed reagents/materials/analysis tools. SME, MRT, MKA, AAA, and BP wrote the paper.