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Research Article

Lack of Support for the Association between GAD2 Polymorphisms and Severe Human Obesity

  • Michael M Swarbrick equal contributor,

    equal contributor Contributed equally to this work with: Michael M Swarbrick, Björn Waldenmaier

    Affiliation: Diabetes Center, University of California, San Francisco, California, United States of America

    X
  • Björn Waldenmaier equal contributor,

    equal contributor Contributed equally to this work with: Michael M Swarbrick, Björn Waldenmaier

    Affiliation: Department of Child and Adolescent Psychiatry, University of Duisburg-Essen, Essen, Germany

    X
  • Len A Pennacchio,

    Affiliation: Department of Energy Joint Genome Institute, Walnut Creek, California, United States of America

    X
  • Denise L Lind,

    Affiliation: Cardiovascular Research Institute, University of California, San Francisco, California, United States of America

    X
  • Martha M Cavazos,

    Affiliation: Diabetes Center, University of California, San Francisco, California, United States of America

    X
  • Frank Geller,

    Affiliation: Institute of Medical Biometry and Epidemiology, Phillips-University of Marburg, Marburg, Germany

    X
  • Raphael Merriman,

    Affiliation: Department of Medicine, University of California, San Francisco, California, United States of America

    X
  • Anna Ustaszewska,

    Affiliation: Department of Energy Joint Genome Institute, Walnut Creek, California, United States of America

    X
  • Mary Malloy,

    Affiliation: Cardiovascular Research Institute, University of California, San Francisco, California, United States of America

    X
  • André Scherag,

    Affiliation: Institute of Medical Biometry and Epidemiology, Phillips-University of Marburg, Marburg, Germany

    X
  • Wen-Chi Hsueh,

    Affiliation: Diabetes Center, University of California, San Francisco, California, United States of America

    X
  • Winfried Rief,

    Affiliation: Department of Psychology, University of Marburg, Marburg, Germany

    X
  • Franck Mauvais-Jarvis,

    Affiliation: Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, Texas, United States of America

    X
  • Clive R Pullinger,

    Affiliation: Cardiovascular Research Institute, University of California, San Francisco, California, United States of America

    X
  • John P Kane,

    Affiliation: Cardiovascular Research Institute, University of California, San Francisco, California, United States of America

    X
  • Robert Dent,

    Affiliation: Ottawa Health Research Institute, Ottawa, Ontario, Canada

    X
  • Ruth McPherson,

    Affiliation: University of Ottawa Heart Institute, Ottawa, Ontario, Canada

    X
  • Pui-Yan Kwok,

    Affiliation: Cardiovascular Research Institute, University of California, San Francisco, California, United States of America

    X
  • Anke Hinney,

    Affiliation: Department of Child and Adolescent Psychiatry, University of Duisburg-Essen, Essen, Germany

    X
  • Johannes Hebebrand,

    Affiliation: Department of Child and Adolescent Psychiatry, University of Duisburg-Essen, Essen, Germany

    X
  • Christian Vaisse mail

    To whom correspondence should be addressed. E-mail: vaisse@diabetes.ucsf.edu

    Affiliation: Diabetes Center, University of California, San Francisco, California, United States of America

    X
  • Published: August 30, 2005
  • DOI: 10.1371/journal.pbio.0030315

About the Authors

Michael M Swarbrick, Martha M Cavazos, Wen-Chi Hsueh, Christian Vaisse
Diabetes Center, University of California, San Francisco, California, United States of America
Björn Waldenmaier, Anke Hinney, Johannes Hebebrand
Department of Child and Adolescent Psychiatry, University of Duisburg-Essen, Essen, Germany
Len A Pennacchio, Anna Ustaszewska
Department of Energy Joint Genome Institute, Walnut Creek, California, United States of America
Denise L Lind, Mary Malloy, Clive R Pullinger, John P Kane, Pui-Yan Kwok
Cardiovascular Research Institute, University of California, San Francisco, California, United States of America
Frank Geller, André Scherag
Institute of Medical Biometry and Epidemiology, Phillips-University of Marburg, Marburg, Germany
Raphael Merriman
Department of Medicine, University of California, San Francisco, California, United States of America
Winfried Rief
Department of Psychology, University of Marburg, Marburg, Germany
Franck Mauvais-Jarvis
Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, Texas, United States of America
Robert Dent
Ottawa Health Research Institute, Ottawa, Ontario, Canada
Ruth McPherson
University of Ottawa Heart Institute, Ottawa, Ontario, Canada

Corresponding Author

Email: vaisse@diabetes.ucsf.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

MMS, BW, LAP, DLL, AH, JH, and CV conceived and designed the experiments. MMS, BW, DLL, and AU performed the experiments. MMS, BW, DLL, MMC, FG, AS, and WCH analyzed the data. LAP, MMC, RM, MM, WR, FMJ, CRP, JPK, RD, RM, PYK, AH, and JH contributed reagents/materials/analysis tools. MMS, LAP, AH, JH, and CV wrote the paper.