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Research Article

The Genomics of Disulfide Bonding and Protein Stabilization in Thermophiles

  • Morgan Beeby equal contributor,

    equal contributor Contributed equally to this work with: Morgan Beeby, Brian D O'Connor

    Affiliations: UCLA-DOE Institute for Genomics and Proteomics, University of California, Los Angeles, California, United States of America, Department of Chemistry and Biochemistry, University of California, Los Angeles, California, United States of America

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  • Brian D O'Connor equal contributor,

    equal contributor Contributed equally to this work with: Morgan Beeby, Brian D O'Connor

    Affiliation: Molecular Biology Institute, University of California, Los Angeles, California, United States of America

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  • Carsten Ryttersgaard,

    Affiliation: UCLA-DOE Institute for Genomics and Proteomics, University of California, Los Angeles, California, United States of America

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  • Daniel R Boutz,

    Affiliation: Molecular Biology Institute, University of California, Los Angeles, California, United States of America

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  • L. Jeanne Perry,

    Affiliation: UCLA-DOE Institute for Genomics and Proteomics, University of California, Los Angeles, California, United States of America

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  • Todd O Yeates mail

    To whom correspondence should be addressed. E-mail: yeates@mbi.ucla.edu

    Affiliations: UCLA-DOE Institute for Genomics and Proteomics, University of California, Los Angeles, California, United States of America, Department of Chemistry and Biochemistry, University of California, Los Angeles, California, United States of America, Molecular Biology Institute, University of California, Los Angeles, California, United States of America

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  • Published: August 23, 2005
  • DOI: 10.1371/journal.pbio.0030309

About the Authors

Morgan Beeby, Carsten Ryttersgaard, L. Jeanne Perry, Todd O Yeates
UCLA-DOE Institute for Genomics and Proteomics, University of California, Los Angeles, California, United States of America
Morgan Beeby, Todd O Yeates
Department of Chemistry and Biochemistry, University of California, Los Angeles, California, United States of America
Brian D O'Connor, Daniel R Boutz, Todd O Yeates
Molecular Biology Institute, University of California, Los Angeles, California, United States of America

Corresponding Author

Email: yeates@mbi.ucla.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

MB and BDO performed the computational analyses. DRB performed the structural database survey and the PDO disulfide experiments. CR determined the crystal structure of GI 18312142. LJP and TOY conceived and designed the studies described.