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Research Article

Basal Immunoglobulin Signaling Actively Maintains Developmental Stage in Immature B Cells

  • Lina E Tze,

    Affiliation: Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America

    ¤ Current address: Division of Immunology and Genetics, The John Curtin School of Medical Research, Australian National University, Canberra, Australia

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  • Brian R Schram,

    Affiliation: Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America

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  • Kong-Peng Lam,

    Affiliation: Institute of Molecular and Cell Biology, Singapore

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  • Kristin A Hogquist,

    Affiliation: Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America

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  • Keli L Hippen,

    Affiliation: Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America

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  • Jiabin Liu,

    Affiliation: Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America

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  • Susan A Shinton,

    Affiliation: Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America

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  • Kevin L Otipoby,

    Affiliation: Center for Blood Research, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Peter R Rodine,

    Affiliation: Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America

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  • Amanda L Vegoe,

    Affiliation: Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America

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  • Manfred Kraus,

    Affiliation: Center for Blood Research, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Richard R Hardy,

    Affiliation: Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America

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  • Mark S Schlissel,

    Affiliation: Department of Molecular and Cell Biology, University of California, Berkeley, California, United States of America

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  • Klaus Rajewsky,

    Affiliation: Center for Blood Research, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Timothy W Behrens mail

    To whom correspondence should be addressed. E-mail: behre001@umn.edu

    Affiliation: Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America

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  • Published: March 08, 2005
  • DOI: 10.1371/journal.pbio.0030082

About the Authors

Lina E Tze, Brian R Schram, Kristin A Hogquist, Keli L Hippen, Jiabin Liu, Peter R Rodine, Amanda L Vegoe, Timothy W Behrens
Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America
Kong-Peng Lam
Institute of Molecular and Cell Biology, Singapore
Susan A Shinton, Richard R Hardy
Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
Kevin L Otipoby, Manfred Kraus, Klaus Rajewsky
Center for Blood Research, Harvard Medical School, Boston, Massachusetts, United States of America
Mark S Schlissel
Department of Molecular and Cell Biology, University of California, Berkeley, California, United States of America

Corresponding Author

Email: behre001@umn.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

LET, BRS, KAH, MK, MSS, KR, and TWB conceived and designed the experiments. LET, BRS, KAH, JL, SAS, PRR, ALV, RRH, and MSS performed the experiments. LET, BRS, KPL, KAH, KLH, JL, SAS, MK, RRH, MSS, KR, and TWB analyzed the data. KPL, KLO, and MK contributed reagents/materials/analysis tools. LET, MK, MSS, KR, and TWB wrote the paper.