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Research Article

SIRT1 Regulates HIV Transcription via Tat Deacetylation

  • Sara Pagans,

    Affiliation: Gladstone Institute of Virology and Immunology, University of California, San Francisco, California, United States of America

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  • Angelika Pedal,

    Affiliation: Gladstone Institute of Virology and Immunology, University of California, San Francisco, California, United States of America

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  • Brian J North,

    Affiliation: Gladstone Institute of Virology and Immunology, University of California, San Francisco, California, United States of America

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  • Katrin Kaehlcke,

    Affiliation: Gladstone Institute of Virology and Immunology, University of California, San Francisco, California, United States of America

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  • Brett L Marshall,

    Affiliation: Gladstone Institute of Virology and Immunology, University of California, San Francisco, California, United States of America

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  • Alexander Dorr,

    Affiliation: Applied Tumorvirology, Deutsches Krebsforschungszentrum, Heidelberg, Germany

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  • Claudia Hetzer-Egger,

    Affiliation: Applied Tumorvirology, Deutsches Krebsforschungszentrum, Heidelberg, Germany

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  • Peter Henklein,

    Affiliation: Institute of Biochemistry, Humboldt University, Berlin, Germany

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  • Roy Frye,

    Affiliation: Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Michael W McBurney,

    Affiliation: Ottawa Regional Cancer Centre, Ottawa, Canada

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  • Henning Hruby,

    Affiliation: Department of Pharmaceutical Sciences, Albert-Ludwigs-University, Freiburg, Germany

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  • Manfred Jung,

    Affiliation: Department of Pharmaceutical Sciences, Albert-Ludwigs-University, Freiburg, Germany

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  • Eric Verdin,

    Affiliation: Gladstone Institute of Virology and Immunology, University of California, San Francisco, California, United States of America

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  • Melanie Ott mail

    To whom correspondence should be addressed. E-mail: mott@gladstone.ucsf.edu

    Affiliations: Gladstone Institute of Virology and Immunology, University of California, San Francisco, California, United States of America, Applied Tumorvirology, Deutsches Krebsforschungszentrum, Heidelberg, Germany

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  • Published: February 08, 2005
  • DOI: 10.1371/journal.pbio.0030041

About the Authors

Sara Pagans, Angelika Pedal, Brian J North, Katrin Kaehlcke, Brett L Marshall, Eric Verdin, Melanie Ott
Gladstone Institute of Virology and Immunology, University of California, San Francisco, California, United States of America
Alexander Dorr, Claudia Hetzer-Egger, Melanie Ott
Applied Tumorvirology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
Peter Henklein
Institute of Biochemistry, Humboldt University, Berlin, Germany
Roy Frye
Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
Michael W McBurney
Ottawa Regional Cancer Centre, Ottawa, Canada
Henning Hruby, Manfred Jung
Department of Pharmaceutical Sciences, Albert-Ludwigs-University, Freiburg, Germany

Corresponding Author

Email: mott@gladstone.ucsf.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

MO conceived and designed the experiments. SP, AP, KK, and BLM performed the experiments. SP, EV, and MO analyzed the data. BJN, AD, CHE, PH, RF, MWM, HH, MJ, and EV contributed reagents/materials/analysis tools. SP, EV, and MO wrote the paper.