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Research Article

Mechanism of Prion Propagation: Amyloid Growth Occurs by Monomer Addition

  • Sean R Collins,

    Affiliation: Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, United States of America

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  • Adam Douglass,

    Affiliation: Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, United States of America

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  • Ronald D Vale,

    Affiliation: Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, United States of America

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  • Jonathan S Weissman mail

    To whom correspondence should be addressed. E-mail: jsw1@itsa.ucsf.edu

    Affiliation: Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, United States of America

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  • Published: September 21, 2004
  • DOI: 10.1371/journal.pbio.0020321

About the Authors

Sean R Collins, Adam Douglass, Ronald D Vale, Jonathan S Weissman
Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, United States of America

Corresponding Author

Email: jsw1@itsa.ucsf.edu

Competing Interests

The authors have declared that no conflicts of interest exist.

Author Contributions

SRC, AD, RDV, and JSW conceived and designed the experiments. SRC and AD performed the experiments. SRC, AD, and JSW analyzed the data. RDV and JSW contributed reagents/materials/analysis tools. SRC and JSW wrote the paper.