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Research Article

A Focused and Efficient Genetic Screening Strategy in the Mouse: Identification of Mutations That Disrupt Cortical Development

  • Konstantinos Zarbalis equal contributor,

    equal contributor Contributed equally to this work with: Konstantinos Zarbalis, Scott R May

    Affiliation: Department of Neurology and the Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, California, United States of America

    X
  • Scott R May equal contributor,

    equal contributor Contributed equally to this work with: Konstantinos Zarbalis, Scott R May

    Affiliation: Department of Neurology and the Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, California, United States of America

    X
  • Yiguo Shen,

    Affiliation: Department of Neurology and the Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, California, United States of America

    X
  • Marc Ekker,

    Affiliation: Loeb Medical Research Institute, University of Ottawa, Ottawa, Ontario, Canada

    X
  • John L. R Rubenstein,

    Affiliation: Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, Langley Porter Psychiatric Institute, University of California at San Francisco, San Francisco, California, United States of America

    X
  • Andrew S Peterson mail

    To whom correspondence should be addressed. E-mail: andpete@itsa.ucsf.edu

    Affiliation: Department of Neurology and the Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, California, United States of America

    X
  • Published: August 17, 2004
  • DOI: 10.1371/journal.pbio.0020219

About the Authors

Konstantinos Zarbalis, Scott R May, Yiguo Shen, Andrew S Peterson
Department of Neurology and the Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, California, United States of America
Marc Ekker
Loeb Medical Research Institute, University of Ottawa, Ottawa, Ontario, Canada
John L. R Rubenstein
Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, Langley Porter Psychiatric Institute, University of California at San Francisco, San Francisco, California, United States of America

Corresponding Author

Email: andpete@itsa.ucsf.edu

Competing Interests

The authors have declared that no conflicts of interest exist.

Author Contributions

ASP conceived the screen. ASP, KZ, SRM, and YS designed and performed the experiments. KZ, SRM, YS, JLRR, and ASP analyzed the data. ME contributed reagents/materials/analysis tools. ASP, KZ, and SRM wrote the paper.