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Research Article

Activation-Induced Cytidine Deaminase Initiates Immunoglobulin Gene Conversion and Hypermutation by a Common Intermediate

  • Hiroshi Arakawa,

    Affiliation: GSF–National Research Center for Environment and Health, Institute for Molecular Radiobiology, Neuherberg-Munich, Germany

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  • Huseyin Saribasak,

    Affiliation: GSF–National Research Center for Environment and Health, Institute for Molecular Radiobiology, Neuherberg-Munich, Germany

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  • Jean-Marie Buerstedde mail

    To whom correspondence should be addressed. E-mail: buersted@gsf.de

    Affiliation: GSF–National Research Center for Environment and Health, Institute for Molecular Radiobiology, Neuherberg-Munich, Germany

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  • Published: July 13, 2004
  • DOI: 10.1371/journal.pbio.0020179

About the Authors

Hiroshi Arakawa, Huseyin Saribasak, Jean-Marie Buerstedde
GSF–National Research Center for Environment and Health, Institute for Molecular Radiobiology, Neuherberg-Munich, Germany

Corresponding Author

Email: buersted@gsf.de

Competing Interests

The authors have declared that no conflicts of interest exist.

Author Contributions

HA and J-MB conceived and designed the experiments. HA and HS performed the experiments. HA, HS, and J-MB analyzed the data. HA and HS contributed reagents/materials/analysis tools. HA and J-MB wrote the paper.