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Research Article

Engineered Biosynthesis of Regioselectively Modified Aromatic Polyketides Using Bimodular Polyketide Synthases

  • Yi Tang,

    Affiliation: Department of Chemical Engineering, Stanford University, Stanford, California, United States of America

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  • Taek Soon Lee,

    Affiliation: Department of Chemistry, Stanford University, Stanford, California, United States of America

    X
  • Chaitan Khosla mail

    To whom correspondence should be addressed. E-mail: ck@chemeng.stanford.edu

    Affiliations: Department of Chemical Engineering, Stanford University, Stanford, California, United States of America, Department of Chemistry, Stanford University, Stanford, California, United States of America, Department of Biochemistry, Stanford University, Stanford, California, United States of America

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  • Published: February 17, 2004
  • DOI: 10.1371/journal.pbio.0020031

About the Authors

Yi Tang, Chaitan Khosla
Department of Chemical Engineering, Stanford University, Stanford, California, United States of America
Taek Soon Lee, Chaitan Khosla
Department of Chemistry, Stanford University, Stanford, California, United States of America
Chaitan Khosla
Department of Biochemistry, Stanford University, Stanford, California, United States of America

Corresponding Author

Email: ck@chemeng.stanford.edu

Competing Interests

A patent application has been filed by Stanford University for aspects of the work described in this paper.

Author Contributions

YT, TSL, and CK conceived and designed the experiments. YT and TSL performed the experiments. YT and TSL analyzed the data. YT wrote the paper.