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Research Article

Inhibition of HIF2α Is Sufficient to Suppress pVHL-Defective Tumor Growth

  • Keiichi Kondo,

    Affiliation: Department of Adult Oncology, Dana–Farber Cancer Institute and Brigham and Womens Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • William Y Kim,

    Affiliation: Department of Adult Oncology, Dana–Farber Cancer Institute and Brigham and Womens Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Mirna Lechpammer,

    Affiliation: Department of Pathology, Dana–Farber Cancer Institute and Brigham and Womens Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • William G Kaelin Jr mail

    To whom correspondence should be addressed. E-mail: william_kaelin@dfci.harvard.edu

    Affiliations: Department of Adult Oncology, Dana–Farber Cancer Institute and Brigham and Womens Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

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  • Published: December 22, 2003
  • DOI: 10.1371/journal.pbio.0000083

About the Authors

Keiichi Kondo, William Y Kim, William G Kaelin Jr
Department of Adult Oncology, Dana–Farber Cancer Institute and Brigham and Womens Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
Mirna Lechpammer
Department of Pathology, Dana–Farber Cancer Institute and Brigham and Womens Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
William G Kaelin Jr
Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

Corresponding Author

Email: william_kaelin@dfci.harvard.edu

Competing Interests

The authors have declared that no conflicts of interest exist.

Author Contributions

KK and WGK conceived and designed the experiments. KK, WYK, and ML performed the experiments. KK, ML, and WGK analyzed the data. KK contributed reagents/materials/analysis tools. WYK and WGK wrote the paper.