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Research Article

The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway

  • Ethan Lee equal contributor,

    equal contributor Contributed equally to this work with: Ethan Lee, Adrian Salic, Roland Krüger

    Affiliations: Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Adrian Salic equal contributor,

    equal contributor Contributed equally to this work with: Ethan Lee, Adrian Salic, Roland Krüger

    Affiliation: Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Roland Krüger equal contributor,

    equal contributor Contributed equally to this work with: Ethan Lee, Adrian Salic, Roland Krüger

    Affiliation: Department of Theoretical Biophysics, Institute of Biology, Humboldt University Berlin, Berlin, Germany

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  • Reinhart Heinrich mail,

    To whom correspondence should be addressed. E-mail: reinhart_heinrich@hms.harvard.edu (RH), Email: marc@hms.harvard.edu (MK)

    Affiliation: Department of Theoretical Biophysics, Institute of Biology, Humboldt University Berlin, Berlin, Germany

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  • Marc W Kirschner mail

    To whom correspondence should be addressed. E-mail: reinhart_heinrich@hms.harvard.edu (RH), Email: marc@hms.harvard.edu (MK)

    Affiliation: Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: October 13, 2003
  • DOI: 10.1371/journal.pbio.0000010

About the Authors

Ethan Lee, Adrian Salic, Marc W Kirschner
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America
Roland Krüger, Reinhart Heinrich
Department of Theoretical Biophysics, Institute of Biology, Humboldt University Berlin, Berlin, Germany
Ethan Lee
Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no conflicts of interest exist.

Author Contributions

EL, AS, RK, RH, and MWK conceived and designed the experiments. EL, AS, RK, and RH performed the experiments. EL, AS, RK, RH, and MWK analyzed the data. EL, AS, RK, RH, and MWK contributed reagents/materials/analysis tools. EL, AS, RK, RH, and MWK wrote the paper.