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Research Article

Extracellular ATP Hydrolysis Inhibits Synaptic Transmission by Increasing pH Buffering in the Synaptic Cleft

  • Rozan Vroman,

    Affiliation: Netherlands Institute for Neuroscience, Amsterdam, the Netherlands

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  • Lauw J. Klaassen,

    Affiliation: Netherlands Institute for Neuroscience, Amsterdam, the Netherlands

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  • Marcus H.C. Howlett,

    Affiliation: Netherlands Institute for Neuroscience, Amsterdam, the Netherlands

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  • Valentina Cenedese,

    Affiliation: Netherlands Institute for Neuroscience, Amsterdam, the Netherlands

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  • Jan Klooster,

    Affiliation: Netherlands Institute for Neuroscience, Amsterdam, the Netherlands

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  • Trijntje Sjoerdsma,

    Affiliation: Netherlands Institute for Neuroscience, Amsterdam, the Netherlands

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  • Maarten Kamermans mail

    m.kamermans@nin.knaw.nl

    Affiliation: Netherlands Institute for Neuroscience, Amsterdam, the Netherlands

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  • Published: May 20, 2014
  • DOI: 10.1371/journal.pbio.1001864

About the Authors

Rozan Vroman, Lauw J. Klaassen, Marcus H.C. Howlett, Valentina Cenedese, Jan Klooster, Trijntje Sjoerdsma, Maarten Kamermans
Netherlands Institute for Neuroscience, Amsterdam, the Netherlands

Corresponding Author

Email: m.kamermans@nin.knaw.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: RV LK MH JK TS MK. Performed the experiments: RV LK MH VC JK TS MK. Analyzed the data: RV LK MH VC JK TS MK. Contributed reagents/materials/analysis tools: RV LK MH JK TS MK. Wrote the paper: RV LK MH VC JK TS MK.