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Research Article

A Tetraploid Intermediate Precedes Aneuploid Formation in Yeasts Exposed to Fluconazole

  • Benjamin D. Harrison,

    Affiliation: Department of Genetics, Cell, and Developmental Biology, University of Minnesota–Twin Cities, Minneapolis, Minnesota, United States of America

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  • Jordan Hashemi,

    Affiliation: Department of Electrical and Computer Engineering, Duke University, Durham, North Carolina, United States of America

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  • Maayan Bibi,

    Affiliation: Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv, Israel

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  • Rebecca Pulver,

    Affiliation: Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv, Israel

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  • Danny Bavli,

    Affiliation: Alexander Grass Center for Bioengineering, The Hebrew University of Jerusalem, Jerusalem, Israel

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  • Yaakov Nahmias,

    Affiliation: Alexander Grass Center for Bioengineering, The Hebrew University of Jerusalem, Jerusalem, Israel

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  • Melanie Wellington,

    Affiliation: Department of Pediatrics, University of Rochester Medical Center, Rochester, New York, United States of America

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  • Guillermo Sapiro,

    Affiliation: Department of Electrical and Computer Engineering, Duke University, Durham, North Carolina, United States of America

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  • Judith Berman mail

    jberman@post.tau.ac.il

    Affiliations: Department of Genetics, Cell, and Developmental Biology, University of Minnesota–Twin Cities, Minneapolis, Minnesota, United States of America, Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv, Israel

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  • Published: March 18, 2014
  • DOI: 10.1371/journal.pbio.1001815

About the Authors

Benjamin D. Harrison, Judith Berman
Department of Genetics, Cell, and Developmental Biology, University of Minnesota–Twin Cities, Minneapolis, Minnesota, United States of America
Jordan Hashemi, Guillermo Sapiro
Department of Electrical and Computer Engineering, Duke University, Durham, North Carolina, United States of America
Maayan Bibi, Rebecca Pulver, Judith Berman
Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv, Israel
Danny Bavli, Yaakov Nahmias
Alexander Grass Center for Bioengineering, The Hebrew University of Jerusalem, Jerusalem, Israel
Melanie Wellington
Department of Pediatrics, University of Rochester Medical Center, Rochester, New York, United States of America

Corresponding Author

Email: jberman@post.tau.ac.il

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: BDH JH MW GS JB. Performed the experiments: BDH JH MW MB RP. Analyzed the data: BDH JH MW RP JB. Contributed reagents/materials/analysis tools: BDH JH MW GS JB YN DB. Wrote the paper: BDH JB.