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Research Article

Brain Endothelial Cells Control Fertility through Ovarian-Steroid–Dependent Release of Semaphorin 3A

  • Paolo Giacobini equal contributor,

    equal contributor Contributed equally to this work with: Paolo Giacobini, Jyoti Parkash, Céline Campagne

    Affiliations: INSERM, Jean-Pierre Aubert Research Center, U837, Development and Plasticity of the Postnatal Brain, Lille, France, UDSL, School of Medicine, Place de Verdun, Lille, France, Institut de Médecine Prédictive et de Recherche Thérapeutique, IFR114, Lille, France

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  • Jyoti Parkash equal contributor,

    equal contributor Contributed equally to this work with: Paolo Giacobini, Jyoti Parkash, Céline Campagne

    Affiliations: INSERM, Jean-Pierre Aubert Research Center, U837, Development and Plasticity of the Postnatal Brain, Lille, France, UDSL, School of Medicine, Place de Verdun, Lille, France, Institut de Médecine Prédictive et de Recherche Thérapeutique, IFR114, Lille, France

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  • Céline Campagne equal contributor,

    equal contributor Contributed equally to this work with: Paolo Giacobini, Jyoti Parkash, Céline Campagne

    Affiliations: INSERM, Jean-Pierre Aubert Research Center, U837, Development and Plasticity of the Postnatal Brain, Lille, France, UDSL, School of Medicine, Place de Verdun, Lille, France, Institut de Médecine Prédictive et de Recherche Thérapeutique, IFR114, Lille, France

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  • Andrea Messina,

    Affiliations: INSERM, Jean-Pierre Aubert Research Center, U837, Development and Plasticity of the Postnatal Brain, Lille, France, UDSL, School of Medicine, Place de Verdun, Lille, France, Institut de Médecine Prédictive et de Recherche Thérapeutique, IFR114, Lille, France

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  • Filippo Casoni,

    Affiliations: INSERM, Jean-Pierre Aubert Research Center, U837, Development and Plasticity of the Postnatal Brain, Lille, France, UDSL, School of Medicine, Place de Verdun, Lille, France, Institut de Médecine Prédictive et de Recherche Thérapeutique, IFR114, Lille, France

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  • Charlotte Vanacker,

    Affiliations: INSERM, Jean-Pierre Aubert Research Center, U837, Development and Plasticity of the Postnatal Brain, Lille, France, UDSL, School of Medicine, Place de Verdun, Lille, France, Institut de Médecine Prédictive et de Recherche Thérapeutique, IFR114, Lille, France

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  • Fanny Langlet,

    Affiliations: INSERM, Jean-Pierre Aubert Research Center, U837, Development and Plasticity of the Postnatal Brain, Lille, France, UDSL, School of Medicine, Place de Verdun, Lille, France, Institut de Médecine Prédictive et de Recherche Thérapeutique, IFR114, Lille, France

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  • Barbara Hobo,

    Affiliations: Netherlands institute for Neuroscience, Amsterdam, The Netherlands, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

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  • Gabriella Cagnoni,

    Affiliation: Candiolo Cancer Institute - FPO (IRCCS) and University of Torino, Department of Oncology, Candiolo, Italy

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  • Sarah Gallet,

    Affiliations: INSERM, Jean-Pierre Aubert Research Center, U837, Development and Plasticity of the Postnatal Brain, Lille, France, UDSL, School of Medicine, Place de Verdun, Lille, France, Institut de Médecine Prédictive et de Recherche Thérapeutique, IFR114, Lille, France

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  • Naresh Kumar Hanchate,

    Affiliations: INSERM, Jean-Pierre Aubert Research Center, U837, Development and Plasticity of the Postnatal Brain, Lille, France, UDSL, School of Medicine, Place de Verdun, Lille, France, Institut de Médecine Prédictive et de Recherche Thérapeutique, IFR114, Lille, France

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  • Danièle Mazur,

    Affiliations: INSERM, Jean-Pierre Aubert Research Center, U837, Development and Plasticity of the Postnatal Brain, Lille, France, UDSL, School of Medicine, Place de Verdun, Lille, France, Institut de Médecine Prédictive et de Recherche Thérapeutique, IFR114, Lille, France

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  • Masahiko Taniguchi,

    Affiliation: Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan

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  • Massimiliano Mazzone,

    Affiliations: Versalius Research Center, VIB, Laboratory of Molecular Oncology and Angiogenesis, Leuven, Belgium, KU Keuven, Versalius Research Center, Leuven, Belgium

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  • Joost Verhaagen,

    Affiliations: Netherlands institute for Neuroscience, Amsterdam, The Netherlands, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

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  • Philippe Ciofi,

    Affiliation: INSERM, Neurocentre Magendie, U862, Université de Bordeaux, Bordeaux, France

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  • Sébastien G. Bouret,

    Affiliations: INSERM, Jean-Pierre Aubert Research Center, U837, Development and Plasticity of the Postnatal Brain, Lille, France, UDSL, School of Medicine, Place de Verdun, Lille, France, Institut de Médecine Prédictive et de Recherche Thérapeutique, IFR114, Lille, France, The Saban Research Institute, Childrens Hospital Los Angeles, University of Southern California, Los Angeles, California, United States of America

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  • Luca Tamagnone,

    Affiliation: Candiolo Cancer Institute - FPO (IRCCS) and University of Torino, Department of Oncology, Candiolo, Italy

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  • Vincent Prevot mail

    vincent.prevot@inserm.fr

    Affiliations: INSERM, Jean-Pierre Aubert Research Center, U837, Development and Plasticity of the Postnatal Brain, Lille, France, UDSL, School of Medicine, Place de Verdun, Lille, France, Institut de Médecine Prédictive et de Recherche Thérapeutique, IFR114, Lille, France

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  • Published: March 11, 2014
  • DOI: 10.1371/journal.pbio.1001808

About the Authors

Paolo Giacobini, Jyoti Parkash, Céline Campagne, Andrea Messina, Filippo Casoni, Charlotte Vanacker, Fanny Langlet, Sarah Gallet, Naresh Kumar Hanchate, Danièle Mazur, Sébastien G. Bouret, Vincent Prevot
INSERM, Jean-Pierre Aubert Research Center, U837, Development and Plasticity of the Postnatal Brain, Lille, France
Paolo Giacobini, Jyoti Parkash, Céline Campagne, Andrea Messina, Filippo Casoni, Charlotte Vanacker, Fanny Langlet, Sarah Gallet, Naresh Kumar Hanchate, Danièle Mazur, Sébastien G. Bouret, Vincent Prevot
UDSL, School of Medicine, Place de Verdun, Lille, France
Paolo Giacobini, Jyoti Parkash, Céline Campagne, Andrea Messina, Filippo Casoni, Charlotte Vanacker, Fanny Langlet, Sarah Gallet, Naresh Kumar Hanchate, Danièle Mazur, Sébastien G. Bouret, Vincent Prevot
Institut de Médecine Prédictive et de Recherche Thérapeutique, IFR114, Lille, France
Barbara Hobo, Joost Verhaagen
Netherlands institute for Neuroscience, Amsterdam, The Netherlands
Barbara Hobo, Joost Verhaagen
Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Gabriella Cagnoni, Luca Tamagnone
Candiolo Cancer Institute - FPO (IRCCS) and University of Torino, Department of Oncology, Candiolo, Italy
Masahiko Taniguchi
Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
Massimiliano Mazzone
Versalius Research Center, VIB, Laboratory of Molecular Oncology and Angiogenesis, Leuven, Belgium
Massimiliano Mazzone
KU Keuven, Versalius Research Center, Leuven, Belgium
Philippe Ciofi
INSERM, Neurocentre Magendie, U862, Université de Bordeaux, Bordeaux, France
Sébastien G. Bouret
The Saban Research Institute, Childrens Hospital Los Angeles, University of Southern California, Los Angeles, California, United States of America

Corresponding Author

Email: vincent.prevot@inserm.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: VP PG PC JV SGB LT. Performed the experiments: JP CC AM FC CV FL BH GC SG NKH DM PG VP. Analyzed the data: VP PG LT. Contributed reagents/materials/analysis tools: MM MT. Wrote the paper: VP LT PG.