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Research Article

Electron Tomography and Simulation of Baculovirus Actin Comet Tails Support a Tethered Filament Model of Pathogen Propulsion

  • Jan Mueller,

    Affiliation: Institute of Molecular Biotechnology, Austrian Academy of Sciences, Vienna, Austria

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  • Julia Pfanzelter,

    Affiliation: Institute of Molecular Biotechnology, Austrian Academy of Sciences, Vienna, Austria

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  • Christoph Winkler,

    Affiliations: RICAM, Austrian Academy of Sciences, Vienna, Austria, Faculty of Mathematics, University of Vienna, Austria

    X
  • Akihiro Narita,

    Affiliations: Nagoya University, Graduate School of Sciences, Structural Biology Research Center and Division of Biological Sciences, Nagoya, Japan, Nagoya University JST PRESTO, 4-1-8 Honcho Kawaguchi, Saitama, Japan

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  • Christophe Le Clainche,

    Affiliation: Laboratoire d'Enzymologie et Biochimie Structurales, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France

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  • Maria Nemethova,

    Affiliation: Institute of Molecular Biotechnology, Austrian Academy of Sciences, Vienna, Austria

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  • Marie-France Carlier,

    Affiliation: Laboratoire d'Enzymologie et Biochimie Structurales, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France

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  • Yuichiro Maeda,

    Affiliation: Nagoya University, Graduate School of Sciences, Structural Biology Research Center and Division of Biological Sciences, Nagoya, Japan

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  • Matthew D. Welch,

    Affiliation: Department of Molecular and Cell Biology, University of California, Berkeley, California, United States of America

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  • Taro Ohkawa,

    Affiliation: Department of Molecular and Cell Biology, University of California, Berkeley, California, United States of America

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  • Christian Schmeiser,

    Affiliations: RICAM, Austrian Academy of Sciences, Vienna, Austria, Faculty of Mathematics, University of Vienna, Austria

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  • Guenter P. Resch,

    Affiliation: Campus Science Support Facilities GmbH, Vienna, Austria

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  • J. Victor Small mail

    Vic.small@imba.oeaw.ac.at

    Affiliation: Institute of Molecular Biotechnology, Austrian Academy of Sciences, Vienna, Austria

    X
  • Published: January 14, 2014
  • DOI: 10.1371/journal.pbio.1001765

About the Authors

Jan Mueller, Julia Pfanzelter, Maria Nemethova, J. Victor Small
Institute of Molecular Biotechnology, Austrian Academy of Sciences, Vienna, Austria
Christoph Winkler, Christian Schmeiser
RICAM, Austrian Academy of Sciences, Vienna, Austria
Christoph Winkler, Christian Schmeiser
Faculty of Mathematics, University of Vienna, Austria
Akihiro Narita, Yuichiro Maeda
Nagoya University, Graduate School of Sciences, Structural Biology Research Center and Division of Biological Sciences, Nagoya, Japan
Akihiro Narita
Nagoya University JST PRESTO, 4-1-8 Honcho Kawaguchi, Saitama, Japan
Christophe Le Clainche, Marie-France Carlier
Laboratoire d'Enzymologie et Biochimie Structurales, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France
Matthew D. Welch, Taro Ohkawa
Department of Molecular and Cell Biology, University of California, Berkeley, California, United States of America
Guenter P. Resch
Campus Science Support Facilities GmbH, Vienna, Austria

Corresponding Author

Email: Vic.small@imba.oeaw.ac.at

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: JVS JM JP CS. Performed the experiments: JM JP CL CW MN. Analyzed the data: JM JP JVS AN. Contributed reagents/materials/analysis tools: CL MFC AN YM TO MDW GPR JVS. Wrote the paper: JVS CS.