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Research Article

Different Levels of Catabolite Repression Optimize Growth in Stable and Variable Environments

  • Aaron M. New,

    Affiliations: VIB Laboratory of Systems Biology, Leuven, Belgium, CMPG Laboratory of Genetics and Genomics, KU Leuven, Leuven, Belgium

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  • Bram Cerulus,

    Affiliations: VIB Laboratory of Systems Biology, Leuven, Belgium, CMPG Laboratory of Genetics and Genomics, KU Leuven, Leuven, Belgium

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  • Sander K. Govers,

    Affiliations: VIB Laboratory of Systems Biology, Leuven, Belgium, CMPG Laboratory of Genetics and Genomics, KU Leuven, Leuven, Belgium

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  • Gemma Perez-Samper,

    Affiliations: VIB Laboratory of Systems Biology, Leuven, Belgium, CMPG Laboratory of Genetics and Genomics, KU Leuven, Leuven, Belgium

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  • Bo Zhu,

    Affiliations: VIB Laboratory of Systems Biology, Leuven, Belgium, CMPG Laboratory of Genetics and Genomics, KU Leuven, Leuven, Belgium

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  • Sarah Boogmans,

    Affiliations: VIB Laboratory of Systems Biology, Leuven, Belgium, CMPG Laboratory of Genetics and Genomics, KU Leuven, Leuven, Belgium

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  • Joao B. Xavier,

    Affiliation: Program in Computational Biology, Memorial Sloan Kettering Cancer Center, New York, New York, United States

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  • Kevin J. Verstrepen mail

    kevin.verstrepen@biw.vib-kuleuven.be

    Affiliations: VIB Laboratory of Systems Biology, Leuven, Belgium, CMPG Laboratory of Genetics and Genomics, KU Leuven, Leuven, Belgium

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  • Published: January 14, 2014
  • DOI: 10.1371/journal.pbio.1001764

About the Authors

Aaron M. New, Bram Cerulus, Sander K. Govers, Gemma Perez-Samper, Bo Zhu, Sarah Boogmans, Kevin J. Verstrepen
VIB Laboratory of Systems Biology, Leuven, Belgium
Aaron M. New, Bram Cerulus, Sander K. Govers, Gemma Perez-Samper, Bo Zhu, Sarah Boogmans, Kevin J. Verstrepen
CMPG Laboratory of Genetics and Genomics, KU Leuven, Leuven, Belgium
Joao B. Xavier
Program in Computational Biology, Memorial Sloan Kettering Cancer Center, New York, New York, United States

Corresponding Author

Email: kevin.verstrepen@biw.vib-kuleuven.be

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: AMN KJV. Performed the experiments: AMN BC SKG SB. Analyzed the data: AMN BC SKG GPS BZ JBX. Wrote the paper: AMN BC GPS KJV.