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Research Article

A20-Deficient Mast Cells Exacerbate Inflammatory Responses In Vivo

  • Klaus Heger equal contributor,

    equal contributor Contributed equally to this work with: Klaus Heger, Kaat Fierens

    Affiliation: Molecular Immunology and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany

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  • Kaat Fierens equal contributor,

    equal contributor Contributed equally to this work with: Klaus Heger, Kaat Fierens

    Affiliations: Laboratory of Immunoregulation, Department of Pulmonary Medicine, University Hospital Ghent, Ghent, Belgium, Department for Molecular Biomedical Research, Vlaams Instituut voor Biotechnologie, Ghent, Belgium

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  • J. Christoph Vahl,

    Affiliation: Molecular Immunology and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany

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  • Attila Aszodi,

    Affiliation: Department of Surgery, Ludwig Maximilians Universität, Munich, Germany

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  • Katrin Peschke,

    Affiliation: Institute for Immunology, Technische Universität Dresden, Dresden, Germany

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  • Dominik Schenten,

    Affiliation: Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Hamida Hammad,

    Affiliations: Laboratory of Immunoregulation, Department of Pulmonary Medicine, University Hospital Ghent, Ghent, Belgium, Department for Molecular Biomedical Research, Vlaams Instituut voor Biotechnologie, Ghent, Belgium

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  • Rudi Beyaert,

    Affiliations: Department for Molecular Biomedical Research, Vlaams Instituut voor Biotechnologie, Ghent, Belgium, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium

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  • Dieter Saur,

    Affiliation: II. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, Munich, Germany

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  • Geert van Loo,

    Affiliations: Department for Molecular Biomedical Research, Vlaams Instituut voor Biotechnologie, Ghent, Belgium, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium

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  • Axel Roers,

    Affiliation: Institute for Immunology, Technische Universität Dresden, Dresden, Germany

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  • Bart N. Lambrecht,

    Affiliations: Laboratory of Immunoregulation, Department of Pulmonary Medicine, University Hospital Ghent, Ghent, Belgium, Department for Molecular Biomedical Research, Vlaams Instituut voor Biotechnologie, Ghent, Belgium, Department of Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands

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  • Mirjam Kool,

    Affiliations: Laboratory of Immunoregulation, Department of Pulmonary Medicine, University Hospital Ghent, Ghent, Belgium, Department for Molecular Biomedical Research, Vlaams Instituut voor Biotechnologie, Ghent, Belgium, Department of Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands

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  • Marc Schmidt-Supprian mail

    supprian@biochem.mpg.de

    Affiliation: Molecular Immunology and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany

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  • Published: January 14, 2014
  • DOI: 10.1371/journal.pbio.1001762

About the Authors

Klaus Heger, J. Christoph Vahl, Marc Schmidt-Supprian
Molecular Immunology and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany
Kaat Fierens, Hamida Hammad, Bart N. Lambrecht, Mirjam Kool
Laboratory of Immunoregulation, Department of Pulmonary Medicine, University Hospital Ghent, Ghent, Belgium
Kaat Fierens, Hamida Hammad, Rudi Beyaert, Geert van Loo, Bart N. Lambrecht, Mirjam Kool
Department for Molecular Biomedical Research, Vlaams Instituut voor Biotechnologie, Ghent, Belgium
Attila Aszodi
Department of Surgery, Ludwig Maximilians Universität, Munich, Germany
Katrin Peschke, Axel Roers
Institute for Immunology, Technische Universität Dresden, Dresden, Germany
Dominik Schenten
Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America
Rudi Beyaert, Geert van Loo
Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium
Dieter Saur
II. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
Bart N. Lambrecht, Mirjam Kool
Department of Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands

Corresponding Author

Email: supprian@biochem.mpg.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: KH KF BNL MK MSS. Performed the experiments: KH KF JCV AA KP. Analyzed the data: KH KF AA HH BNL MK MSS. Contributed reagents/materials/analysis tools: DS HH RB DS GL AR. Wrote the paper: KH KF BNL MK MSS. Performed most experiments: KH. Performed lung experiments: KF. Supervised work in Ghent: MK. Supervised work in Munich: MSS.