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Research Article

Direct Type I IFN but Not MDA5/TLR3 Activation of Dendritic Cells Is Required for Maturation and Metabolic Shift to Glycolysis after Poly IC Stimulation

  • Austin Pantel equal contributor,

    equal contributor Contributed equally to this work with: Austin Pantel, Angela Teixeira

    Affiliation: Laboratory of Cellular Physiology and Immunology and Christopher H. Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, New York, United States of America

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  • Angela Teixeira equal contributor,

    equal contributor Contributed equally to this work with: Austin Pantel, Angela Teixeira

    Affiliation: Laboratory of Cellular Physiology and Immunology and Christopher H. Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, New York, United States of America

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  • Elias Haddad,

    Affiliation: Vaccine and Gene Therapy Institute of Florida, Port St. Lucie, Florida, United States of America

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  • Elizabeth G. Wood,

    Affiliation: William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, London, United Kingdom

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  • Ralph M. Steinman †,

    † Deceased.

    Affiliation: Laboratory of Cellular Physiology and Immunology and Christopher H. Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, New York, United States of America

    RMS and MPL also contributed equally to this work.

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  • M. Paula Longhi mail

    m.longhi@qmul.ac.uk

    Affiliations: Laboratory of Cellular Physiology and Immunology and Christopher H. Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, New York, United States of America, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, London, United Kingdom

    RMS and MPL also contributed equally to this work.

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  • Published: January 07, 2014
  • DOI: 10.1371/journal.pbio.1001759
  • Featured in PLOS Collections

About the Authors

Austin Pantel, Angela Teixeira, Ralph M. Steinman, M. Paula Longhi
Laboratory of Cellular Physiology and Immunology and Christopher H. Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, New York, United States of America
Elias Haddad
Vaccine and Gene Therapy Institute of Florida, Port St. Lucie, Florida, United States of America
Elizabeth G. Wood, M. Paula Longhi
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, London, United Kingdom

Corresponding Author

Email: m.longhi@qmul.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: MPL RMS. Performed the experiments: AP AT EGW. Analyzed the data: AP AT. Contributed reagents/materials/analysis tools: EH. Wrote the paper: AP MPL.